Expression and Modulation of Blood-brain Monocarboxylate Transporters
Neural activity and its high metabolic energy demands are sustained by the metabolic fuels and nutrients provided by the circulation. Recently, the molecular identity and primary structure of membrane carriers for monocarboxylic acids, a group of key metabolites in the central nervous system, were discovered. We have investigated these transporters in brain using protein and transcript specific probes to detect their expression and localization. These findings are now extended to the human brain and its cerebral vasculature.
KeywordsKetone Body Brain Endothelial Cell Monocarboxylic Acid Cerebral Vasculature Monocarboxylate Transporter
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