Abstract
Neural activity and its high metabolic energy demands are sustained by the metabolic fuels and nutrients provided by the circulation. Recently, the molecular identity and primary structure of membrane carriers for monocarboxylic acids, a group of key metabolites in the central nervous system, were discovered. We have investigated these transporters in brain using protein and transcript specific probes to detect their expression and localization. These findings are now extended to the human brain and its cerebral vasculature.
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Froberg, M. K., Gerhart, D. Z., Enerson, B. E., Manivel, C., Guzman-Paz, M., Seacotte, N., and Drewes, L. R., 2001, Expression of monocarboxylate transporters MCT1 and MCT2 in normal and neoplastic human CNS tissues. Neuroreport 12: 761–765.
Gerhart, D. Z., Enerson, B. E., Leino, R. L., Zhdankina, O., and Drewes, L. R., 1997, Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am. J. Phys. 273: E207–E213.
Halestrap, A. P., 1999, The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 343: 281–299.
Leino, R. L., Gerhart, D. Z., and Drewes, L. R., 1999, Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study. Brain Res. Dev. Brain Res. 113: 47–54.
Leino., R. L., Gerhart, D. Z, Duelli, R., Enerson, B. E., and Drewes, L. R., 2001, Dietinduced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem. Inl 38: 519–527.
Price, N. T., Jackson, V. N., and Halestrap, A. P., 1998, Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329: 321–328.
Yoon, H., and Philp, N. J., 1998, Genomic structure and developmental expression of the chicken monocarboxylate transporter MCT3 gene. Exp. Eye Res. 67: 417–424.
Yoon, H., Donoso, L. A., and Philp, N. J., 1999, Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22ql2.3-ql32. Genomics 60: 366–370.
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© 2001 Springer Science+Business Media New York
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Drewes, L.R., Gerhart, D.Z., Leino, R.L., Enerson, B.E. (2001). Expression and Modulation of Blood-brain Monocarboxylate Transporters. In: Kobiler, D., Lustig, S., Shapira, S. (eds) Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0579-2_2
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DOI: https://doi.org/10.1007/978-1-4615-0579-2_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5141-2
Online ISBN: 978-1-4615-0579-2
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