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Transcytosis and Signalling of Pneumococci at the Blood Brain Barrier

  • Joerg R. Weber
  • Elaine I. Tuomanen

Abstract

Meningeal pathogens, including pneumococci, meningococci and Haemophilus influenzae,attach to and colonize nasopharyngeal cells, invade to cause bacteremia and, in the presence of sustained high level bacteremia, they cross cerebral microvessels to enter the subarachnoid space and cause meningitis. A common feature for all three pathogens is the two step invasive process. First, adherence is enabled by multiple ligand receptor interactions usually between host cell glycoconjugates and bacterial proteins. Following adherence, a second step actively upregulates a new ligand receptor pair required to penetrate the human cell. At the level of the blood brain barrier, each bacteria has solved this paradigm in a different manner. In vitro the process requires several hours and bacteria strictly regulate the composition of their surfaces so as to direct trafficking of their “passenger” vacuole across the cell.

Keywords

Blood Brain Barrier Bacterial Meningitis Streptococcus Pneumoniae Pneumococcal Meningitis Secretory Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Joerg R. Weber
    • 1
  • Elaine I. Tuomanen
    • 2
  1. 1.Dept of NeurologyUniversitaetsklinikum Charit 9BerlinGermany
  2. 2.Dept of Infectious DiseasesSt. Jude Children’s Research HospitalMemphisUSA

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