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Infant Feeding and Autoimmune Diabetes

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Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 503))

Abstract

Type 1 (insulin-dependent) Diabetes Mellitus is a chronic autoimmune disorder of genetically susceptible hosts, caused by the interaction of uncertain environmental factors with the products of 20+ predisposing genes.1 Self-reactive T lymphocytes, targeting components of the pancreatic islets of Langerhans, accumulate in that locale early in life and begin a slow process, called “prediabetes”. Progressive prediabetes leads to the expansion of autoreactive T cells,2 with increasingly efficient destruction of insulin producing beta cells and their precursors.

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Authors and Affiliations

  1. The Hospital For Sick Children, Research Institute IIIR Program, University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada

    H.-Michael Dosch

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  1. H.-Michael Dosch
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  2. D. J. Becker
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Editors and Affiliations

  1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    Margarett K. Davis

  2. New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA

    Charles E. Isaacs

  3. University of Göteborg, Göteborg, Sweden

    Lars Å. Hanson

  4. University of Arizona, Tucson, Arizona, USA

    Anne L. Wright

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Dosch, HM., Becker, D.J. (2002). Infant Feeding and Autoimmune Diabetes. In: Davis, M.K., Isaacs, C.E., Hanson, L.Å., Wright, A.L. (eds) Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation. Advances in Experimental Medicine and Biology, vol 503. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0559-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-0559-4_15

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