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Spray-Drying of Proteins

  • Chapter
Rational Design of Stable Protein Formulations

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 13))

Abstract

The answer to this question is simple: spray-drying is an effective, efficient means of producing peptide/protein-loaded powders suitable for pulmonary delivery. In addition, fine powders of proteins have application in other delivery systems (e.g., implantable pumps). If the correct formulation and spray-drying conditions can be identified, then a product can be obtained with a high yield and having a large fine-particle dose. Spray-drying is therefore a realistic alternative to the widespread practice of air-jet milling used to produce powders of low molecular-weight actives for inhalation. Indeed, air-jet milling should probably be avoided with peptides or proteins, because of possible problems of physical instability and inactivation. Apart from these considerations, spray-drying is also a suitable technique for embedding sensitive peptides or proteins in stabilizing excipients (“carriers”) such as disaccharides or amino acids.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Friedrich-Alexander University, Erlangen, Germany

    Geoffrey Lee

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  1. Geoffrey Lee
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Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, Colorado, USA

    John F. Carpenter  & Mark C. Manning  & 

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© 2002 Springer Science+Business Media New York

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Lee, G. (2002). Spray-Drying of Proteins. In: Carpenter, J.F., Manning, M.C. (eds) Rational Design of Stable Protein Formulations. Pharmaceutical Biotechnology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0557-0_6

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  • DOI: https://doi.org/10.1007/978-1-4615-0557-0_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5131-3

  • Online ISBN: 978-1-4615-0557-0

  • eBook Packages: Springer Book Archive

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