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PAS Proteins: Regulators and Sensors of Development and Physiology pp 205–230Cite as

Hormones, Obesity, Learning, and Breathing — the Many Functions of Mammalian Single-Minded Genes

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Abstract

There are two mammalian Single-minded (Sim) genes. Both of them have been shown to play important roles during normal mammalian embryonic development. Each of them has also been directly implicated in contributing to the genetic causes of specific human conditions such as obesity and learning disability. While much is inferred about the genes’ functions by means of mutation and over-expression studies in transgenic mouse models, little is known about what causes their dysfunction to lead to developmental abnormalities.

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  1. Carnegie Institution of Washington, Baltimore, MD, 21211, USA

    Chen-Ming Fan

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  1. The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Stephen T. Crews

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Fan, CM. (2003). Hormones, Obesity, Learning, and Breathing — the Many Functions of Mammalian Single-Minded Genes. In: Crews, S.T. (eds) PAS Proteins: Regulators and Sensors of Development and Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0515-0_9

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