Methoprene-Tolerant, A PAS Gene Critical for Juvenile Hormone Signaling in Drosophila Melanogaster

  • Thomas G. Wilson


Since their discovery, bHLH-PAS genes have been found to be widespread among organisms, ranging from prokaryotes to humans (1,2). Proteins encoded by genes in the PAS family function to sense environmental and developmental signals that reach an organism or a tissue within an organism, and they initiate a response that usually involves the regulation of target gene(s). As discussed in these chapters, the environmental signals range from chemical (planar aromatic hydrocarbons; oxygen tension) to physical (light). The developmental signals are less well-understood, but PAS mutants have shown the importance of PAS genes during development (3, 4, 5, 6, 7, 8, 9, 10). The availability of the genomic sequence of humans, Drosophila melanogaster, and Caenorhabditis elegans within the past several years has allowed the constellation of PAS genes to be identified in these organisms, and it seems unlikely that new PAS genes having functions that are radically different from those of the present family members will be uncovered. So, our task at present is to elucidate the functions and molecular mechanisms of these genes.


Juvenile Hormone Insecticide Resistance Aryl Hydrocarbon Receptor Pupal Development Juvenile Hormone Analog 
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© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Thomas G. Wilson
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

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