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The ACTH Receptor and Its Mutations

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The Acth Axis: Pathogenesis, Diagnosis and Treatment

Part of the book series: Endocrine Updates ((ENDO,volume 21))

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Abstract

ACTH stimulates steroidogenesis by acting on a single highly specific cell surface receptor in the adrenal cortex. ACTH also has weaker affinity for all the other four members of the melanocortin receptor family, which are expressed in a variety of tissues. The principal endogenous agonists for these other receptors are α- and γ- melanocyte stimulating hormones (α -and γ- MSH), but these peptides are unable to bind to the ACTH receptor. This chapter aims to describe the characterization of this receptor prior to its cloning in 1992 and the subsequent studies of receptor regulation and function. Finally, the defects of this receptor in human disease are described.

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Authors and Affiliations

  1. Division of Endocrinology, St-Bartholomew’s Hospital, London, EC1A 7BE, Great Britain

    Adrian J. L. Clark & Peter J. King

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  1. Adrian J. L. Clark
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  1. Division of Endocrinology, Diabetology & Metabolism, University Hospital (CHUV), Lausanne, Switzerland

    Rolf C. Gaillard M.D.

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Clark, A.J.L., King, P.J. (2003). The ACTH Receptor and Its Mutations. In: Gaillard, R.C. (eds) The Acth Axis: Pathogenesis, Diagnosis and Treatment. Endocrine Updates, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0501-3_9

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  • DOI: https://doi.org/10.1007/978-1-4615-0501-3_9

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