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Pituitary Corticotroph SOCS-3: An Important Regulator of Pomc Gene Expression

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The Acth Axis: Pathogenesis, Diagnosis and Treatment

Part of the book series: Endocrine Updates ((ENDO,volume 21))

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Abstract

Pituitary corticotroph POMC gene expression is regulated by hypothalamic CRH as well as several neuroimmunoendocrine modulators, e.g. gp130 cytokines (see also Chapter 6). While CRH action is mediated by a cAMPdependent pathway, effects of gp130 cytokines are mediated by the JakSTAT signaling cascade. Synergistic crosstalk of different stimuli and signaling cascades enables the HPA axis to show a rapid and profound response to inflammatory and stress stimuli.

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  1. Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-Universitat, Munich, 81366, Germany

    Christoph J Auernhammer

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  1. Division of Endocrinology, Diabetology & Metabolism, University Hospital (CHUV), Lausanne, Switzerland

    Rolf C. Gaillard M.D.

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Auernhammer, C.J. (2003). Pituitary Corticotroph SOCS-3: An Important Regulator of Pomc Gene Expression. In: Gaillard, R.C. (eds) The Acth Axis: Pathogenesis, Diagnosis and Treatment. Endocrine Updates, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0501-3_7

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