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CRH-Receptors and their Ligands

  • Chapter
The Acth Axis: Pathogenesis, Diagnosis and Treatment

Part of the book series: Endocrine Updates ((ENDO,volume 21))

Abstract

It has long been postulated that the pituitary gland plays a central role in mediating the stress response (11). Later, it was hypothesized that higher brain centers are involved in the regulation of pituitary ACTH release and that the pituitary gland is under control of hypothalamic factors which would reach the adenohypophysis via hypothalamic-hypophyseal blood vessels (2). Further evidence for the existence of this hypothetical hypothalamic corticotropin releasing factor (CRF) was provided by demonstrating that hypothalamic organ extracts stimulated pituitary ACTH release (3 4).

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Authors and Affiliations

  1. Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, and Ludwig Boltzmann Institute of Experimental Endocrinology, Vienna, Austria

    Christina Maier, Harald Kotzmann & Anton Luger

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  1. Christina Maier
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  2. Harald Kotzmann
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  1. Division of Endocrinology, Diabetology & Metabolism, University Hospital (CHUV), Lausanne, Switzerland

    Rolf C. Gaillard M.D.

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Maier, C., Kotzmann, H., Luger, A. (2003). CRH-Receptors and their Ligands. In: Gaillard, R.C. (eds) The Acth Axis: Pathogenesis, Diagnosis and Treatment. Endocrine Updates, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0501-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-0501-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5108-5

  • Online ISBN: 978-1-4615-0501-3

  • eBook Packages: Springer Book Archive

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