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High-Definition Magnetic Resonance of Genetically Modified Mice

  • Chapter
The Physiological Genomics of the Critically Ill Mouse

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 16))

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Abstract

The genetic data that is delivered by the worldwide genome projects, combined with the advances in the genetic manipulation of laboratory animals, provide exciting possibilities for testing detailed hypotheses on the role of specific gene products in the normal function of tissues and organs as well as in disease processes. Transgenic and knock-out models have therefore acquired a central role in modern biomedical research. These developments have created a great need for innovative technologies that are suited for the parameters in situ analysis of the functional consequences of gene manipulation in transgenic and knock-out models. The technology of choice should be highly sensitive to functional alterations, deliver multiple read-out parameters and preferably be non-invasive. MR techniques are qualified to fulfill an important role in functional genomics research because they are able to provide a multiplicity of structural, functional and metabolic parameters in a single study. In addition, MR is non-perturbing to biological systems. No significant effects on vital processes have been observed in studies addressing the potentially harmful effects of the high magnetic fields used in biomedical MR research1. The downside of this non-invasive character is that the technique is relatively insensitive and often requires relatively long measurement times. This makes MR less attractive as a largescale screening tool and qualifies it as a modality for the small-scale, indepth phenotyping of mice that have proven of particular interest on the basis of less elaborate procedures. Nevertheless, several MR groups make substantial efforts to develop high-throughput devices for mouse phenotyping purposes (e.g., 2).

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Authors and Affiliations

  1. Department of Biomedical NMR, Faculty of Biomedical Engineering, Eindhoven University of Technology, The Netherlands

    Klaas Nicolay, Gustav J. Strijkers & Jeanine J. Prompers

  2. Department of Movement Sciences, Maastricht University, The Netherlands

    Maarten R. Drost

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  1. Klaas Nicolay
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  2. Gustav J. Strijkers
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  3. Jeanine J. Prompers
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  4. Maarten R. Drost
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  1. Department of Physiology Academic Medical Center, University of Amsterdam, The Netherlands

    Can Ince

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Nicolay, K., Strijkers, G.J., Prompers, J.J., Drost, M.R. (2004). High-Definition Magnetic Resonance of Genetically Modified Mice. In: Ince, C. (eds) The Physiological Genomics of the Critically Ill Mouse. Basic Science for the Cardiologist, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0483-2_8

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  • DOI: https://doi.org/10.1007/978-1-4615-0483-2_8

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