Mouse Models of Sepsis
A wide array of murine models has been described for identifying pathophysiological and molecular mechanisms that underlie sepsis and septic shock. However, the investigator’s preference for a specific type of model often remains somewhat hampered since manifold aspects of physiological and technical properties have to be taken into account. Depending on the questions being asked, a standardized and simplified experimental approach or a more complex and hence putatively realistic septic challenge may be appropriate. However, even with implementation of recommended therapeutic strategies and thorough transformation of a typical clinical intensive care setting (including mechanical ventilation and invasive monitoring of organ function) into experiments in mice, the ideal model still may not exist. This chapter will review available models of murine sepsis in order to serve as guideline for experimental study design.
KeywordsStarch Pneumonia Morphine Pseudomonas Gall
Unable to display preview. Download preview PDF.
- 4.Koch T, Geiger S, Ragaller MJ (2001) Monitoring of organ dysfunction in sepsis/systemic inflammatory response syndrome: novel strategies. J Am Soc Nephrol 12 Suppl 17:S53–S59Google Scholar
- 13.Zanetti G, Heumann D, Gerain J et al. (1992) Cytokine production after intravenous or peritoneal gram-negative bacterial challenge in mice. Comparative protective efficacy of antibodies to tumor necrosis factor-alpha and to lipopolysaccharide. J Immunol 148:1890–1897Google Scholar
- 26.Baker CC, Chaudry IH, Gaines HO, Baue AE (1983) Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94:331–335Google Scholar
- 38.Vincent JL (2001) Hemodynamic support in septic shock. Intensive Care Med 27 Suppl 1:580-S92Google Scholar