Mouse Models of Sepsis
A wide array of murine models has been described for identifying pathophysiological and molecular mechanisms that underlie sepsis and septic shock. However, the investigator’s preference for a specific type of model often remains somewhat hampered since manifold aspects of physiological and technical properties have to be taken into account. Depending on the questions being asked, a standardized and simplified experimental approach or a more complex and hence putatively realistic septic challenge may be appropriate. However, even with implementation of recommended therapeutic strategies and thorough transformation of a typical clinical intensive care setting (including mechanical ventilation and invasive monitoring of organ function) into experiments in mice, the ideal model still may not exist. This chapter will review available models of murine sepsis in order to serve as guideline for experimental study design.
KeywordsSeptic Shock Multiple Organ Dysfunction Syndrome Cecal Ligation Intraabdominal Abscess Septic Mouse
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