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Frontiers in Cardiovascular Health pp 19–28Cite as

The Role of Inflammation in Cardiac Function and Repair

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Part of the book series: Progress in Experimental Cardiology ((PREC,volume 9))

Summary

Reperfusion of the infarcted myocardium is associated with an intense inflammatory reaction, which may extend ischemic injury, but is also crucial for cardiac repair, improving patient survival. Myocardial necrosis induces complement activation and free radical generation, triggering a cytokine cascade initiated by Tumor Necrosis Factor (TNF)-α release. In addition, chemokine expression is markedly induced in the infarcted myocardium and may have a role in regulating leukocyte infiltration, angiogenesis and granulation tissue formation. Bone marrow-derived stem cells may also be recruited in the infarct thus participating in cardiac repair. Elucidating the complex interactions and regulatory mechanisms responsible for infarct healing may allow us to design effective inflammation-related interventions for the treatment of myocardial infarction.

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Author information

Authors and Affiliations

  1. Departments of Medicine and Pediatrics, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA

    Mark L. Entman M.D., Keith A. Youker, Venkatesh Lakshminarayanan, Tareck O. Nossuli, Oliver Dewald, C. Wayne Smith & Nikolaos G. Frangogiannis

  2. DeBakey Heart Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA

    Mark L. Entman M.D., Keith A. Youker, Venkatesh Lakshminarayanan, Tareck O. Nossuli, Oliver Dewald, C. Wayne Smith & Nikolaos G. Frangogiannis

Authors
  1. Mark L. Entman M.D.
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  2. Keith A. Youker
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  3. Venkatesh Lakshminarayanan
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  4. Tareck O. Nossuli
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  5. Oliver Dewald
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  6. C. Wayne Smith
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  7. Nikolaos G. Frangogiannis
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Corresponding author

Correspondence to Mark L. Entman M.D. .

Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director), H. Ivan Berkowitz MBA (Consultant) & Pawan K. Singal PhD, DSc (Professor) (Distinguished Professor and Director),  (Consultant) &  (Professor)

  2. Institute of Circulatory & Respiratory Health, Canadian Institutes of Health Research, Vancouver, Canada

    Arun Chockalingam PhD (Assistant Director) (Assistant Director)

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© 2003 Springer Science+Business Media New York

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Entman, M.L. et al. (2003). The Role of Inflammation in Cardiac Function and Repair. In: Dhalla, N.S., Chockalingam, A., Berkowitz, H.I., Singal, P.K. (eds) Frontiers in Cardiovascular Health. Progress in Experimental Cardiology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0455-9_2

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  • DOI: https://doi.org/10.1007/978-1-4615-0455-9_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5085-9

  • Online ISBN: 978-1-4615-0455-9

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