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Does Reperfusion Cause Any Injury to the Myocardium?

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Frontiers in Cardiovascular Health

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 9))

Summary

Enormous effort has been made during the past three decades to explain the pathologic events which occur upon reperfusion of the previously ischemic heart in animals. Experimental studies have described potentially harmful effects of reperfusion, a phenomenon called “reperfusion injury”. It is based on the observations in different animals that some myocardial damage occurs upon reperfusion if it is not instituted within a certain time-period of the ischemic insult. Although reperfusion has been shown as the most efficient treatment strategy for acute myocardial infarction in humans, arrhythmias and myocardial depression (cardiac stunning) have been observed upon reperfusion in patients with acute myocardial infarction; these harmful effects are temporary. In fact, the hard-core evidence that reperfusion causes myocardial injury in human is lacking and this is primarily due to the fact that a host of drugs are administered before inducing reperfusion by angioplasty, thrombolytic therapy or coronary bypass surgery. The purpose of this article is to summarize the current knowledge regarding the relationship between reperfusion and reperfusion injury and their implications in clinical management. De spite abundant information concerning the reperfusion-related injury, it is not clear whether reperfusion causes further injury to the ischemia-damaged cardiomyocytes or it is the delayed effect of ischemia per se. In addition, modifications of the reperfusion conditions have not been shown to improve the long-term damage to the myocardium. Thus, some caution should be exercised in interpreting the data from animal experiments to human until long-term results on ischemia-reperfusion injury are available.

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Authors and Affiliations

  1. Department of Internal Medicine University Hospital Motol, Charles University Prague, Czech Republic

    Petr Ostadal

  2. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Irena Zdobnicka & Prof. Dr. Naranjan S. Dhalla

  3. Department of Physiology, Faculty of Medicine University of Manitoba, Winnipeg, Canada

    Irena Zdobnicka & Prof. Dr. Naranjan S. Dhalla

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  1. Petr Ostadal
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Correspondence to Naranjan S. Dhalla .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director), H. Ivan Berkowitz MBA (Consultant) & Pawan K. Singal PhD, DSc (Professor) (Distinguished Professor and Director),  (Consultant) &  (Professor)

  2. Institute of Circulatory & Respiratory Health, Canadian Institutes of Health Research, Vancouver, Canada

    Arun Chockalingam PhD (Assistant Director) (Assistant Director)

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Ostadal, P., Zdobnicka, I., Dhalla, N.S. (2003). Does Reperfusion Cause Any Injury to the Myocardium?. In: Dhalla, N.S., Chockalingam, A., Berkowitz, H.I., Singal, P.K. (eds) Frontiers in Cardiovascular Health. Progress in Experimental Cardiology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0455-9_11

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