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Xenotransplantation: An Overview

  • Chapter
Pathophysiology of Cardiovascular Disease

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

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Summary

Interest in xenotransplantation has increased significantly as a possible response to the critical organ shortage crisis that exists in clinical transplantation today. The pig has been suggested to be the most suitable animal for human xenotransplantation, however, many barriers still exist to the clinical application of xenotransplantation.

This review takes a brief look at the history of clinical xenotransplantation, the choice of organ donor, the obstacles to xenotransplantation and attempts to overcome them. Xenografted organs will likely be used as a bridge to allotransplantation before being used as full blown replacements for human organs. There is much progress that has been made, but still much to do. With perseverance and good science, solutions are likely to be found.

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Authors and Affiliations

  1. The Division of Cardiac Surgery, Department of Surgery, Edmonton, Alberta, Canada

    Dr. Rizwan A. Manji & Arvind Koshal

  2. Surgical Medical Research Institute, 1074 Dentistry/Pharmacy Centre, University of Alberta, T6G 2N8, Edmonton, Alberta, Canada

    Dr. Rizwan A. Manji, Jacqueline S. Manji & Ray V. Rajotte

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  1. Dr. Rizwan A. Manji
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  2. Jacqueline S. Manji
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  3. Ray V. Rajotte
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  4. Arvind Koshal
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Correspondence to Rizwan A. Manji .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

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Manji, R.A., Manji, J.S., Rajotte, R.V., Koshal, A. (2004). Xenotransplantation: An Overview. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_39

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