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Phytoestrogens and Cardiovascular Disorders

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Book cover Pathophysiology of Cardiovascular Disease

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

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Summary

Dietary intake of phytoestrogens has been associated with a reduction in risk of cardiovascular disorders including coronary heart disease, hypertension and atherosclerosis. Phytoestrogens have long been found to be structurally similar to the female sex hormone, 17ß-estradiol, and have a wide range of estrogenic effects. Like 17ß-estradiol, phytoestrogens such as genistein have been suggested to exert its cardioprotective actions through favourable alteration of serum lipoprotein levels. There is also evidence indicating the role of isoflavones as tyrosine kinase inhibitors, calcium channel antagonists as well as antioxidants. Since genistein has a higher affinity for estrogen receptor ß than for estrogen receptor α, it is predicted to have a preferential protective effect on the cardiovascular system without significant actions on the reproductive system. Therefore, genistein and related compounds may have superiority over 17ß-estradiol as potential therapeutic agent.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Level 2, Laboratory Block 21 Sassoon Road, Hong Kong

    Ricky Y. K. Man, Susan W. S. Leung, Hwee Teoh, Adrian Quan, Wendy Keung & Mary Y. K. Lee

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

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Man, R.Y.K., Leung, S.W.S., Teoh, H., Quan, A., Keung, W., Lee, M.Y.K. (2004). Phytoestrogens and Cardiovascular Disorders. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_35

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