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ADP-Ribosylation and the Cardiovascular System

  • Chapter
Pathophysiology of Cardiovascular Disease

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

Summary

Post-translational modification of proteins with ADP-ribose alters their physical and functional characteristics. The relationship between ADP-ribosylation and several bacterial toxins (e.g. cholera toxin, pertussis toxin, diphtheria toxin) is well established. In contrast, the function of the endogenous ADP-ribosyl transferase enzyme is poorly understood. The latter statement also applies to poly(ADP-ribose) polymerase, although PARP has become familiar due to its association with apoptosis. This article summarizes the enzymology of ADP-ribosylation, reviews the various cellular processes in which it may participate and examines the possible functions of ADP-ribosylation in cardiovascular tissues. Poly (ADP-ribosyl) ation, which has been linked to ischemia-reperfusion injury, is known to participate in DNA repair. In contrast, mono (ADP-ribosyl) ation is best known for modulating G protein function. In the cardiovascular system, mono(ADP-ribosyl)ation may exert effects by modifying growth factors or by transducing the intracellular effects of nitric oxide. Alternatively, mono (ADP-ribosyl) ation could influence cell migration by modifying cytoskeletal proteins. By also examining the role of ADP-ribosylation in other systems, considerable insight into the possible contributions of ADP-ribosylation to cardiovascular function can be extrapolated to both normal and pathological conditions.

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  1. Institute of Cardiovascular Sciences, St. Boniface Research Centre, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada

    Lorraine Yau & Peter Zahradka

  2. Department of Physiology, University of Manitoba, Canada

    Lorraine Yau & Peter Zahradka

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

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Yau, L., Zahradka, P. (2004). ADP-Ribosylation and the Cardiovascular System. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_27

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