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Pathophysiology of Cardiovascular Disease pp 303–326Cite as

Mechanisms of Cardioprotection against Ischemia Reperfusion Injury

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Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

Summary

The high incidence of morbidity and mortality associated with acute myocardial ischemia (AMI) has stimulated substantial research to salvage the dying myocardium. Early restoration of flow to the ischemic myocardium by different interventions has significantly reduced the mortality associated with the acute coronary syndrome but could not improve the morbidity. Accordingly, the possibility of reperfusion injury, and not ischemic injury, as the cause of post ischemic myocardial dysfunction is being considered seriously. Ventricular arrhythmias, myocardial stunning and cell death are the prominent sequels to post ischemic reperfusion. Although thrombolytic and other therapies like percutaneous transluminal angioplasty and coronary artery bypass grafting have significantly increased the rate of survival of AMI patients, these procedures have also spurred interest in the phenomena of ischemia reperfusion injury. In view of the immense clinical consequences of ischemia reperfusion in humans, a large number of animal studies have been carried out to understand the pathophysiology and therapy. This article elaborates different mechanisms which have been suggested to cause ischemia reperfusion injury as well as therapeutic modalities that have shown promise in reducing the associated cardiac abnormalities.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H2A6, 351 Tache Avenue, Winnipeg, Manitoba, Canada

    Raja B. Singh & Dr. Naranjan S. Dhalla (Professor and Director)

  2. Department of Physiology, Faculty of Medicine, University of Manitoba, R2H2A6, Winnipeg, Canada

    Raja B. Singh & Dr. Naranjan S. Dhalla (Professor and Director)

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Correspondence to Naranjan S. Dhalla .

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  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

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Singh, R.B., Dhalla, N.S. (2004). Mechanisms of Cardioprotection against Ischemia Reperfusion Injury. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_23

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