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Temperature Dependence of Ischemic Preconditioning

  • J. S. Juggi
  • E. A. R. Ghadhanfar
  • M. Barac-Nieto
  • S. Joseph
Part of the Progress in Experimental Cardiology book series (PREC, volume 10)

Summary

Temperature dependence of ischemic preconditioning was evaluated in the globally ischemic model of Langendorff perfused rat heart. The results of these studies indicate that hyperthermic (42°) preconditioning offered optimal preservation of myocardial and coronary vascular functions during prolonged periods of ischemia. The cardioprotection was significantly better than at nor mo thermic or hypothermic preconditioning temperatures. The exact mechanism(s) of this protection is not clear, but the results of this study do indicate a role of HSP70, particularly the nuclear translocation of this protein during hyperthermic preconditioning.

Key words

hyperthermic ischemic preconditioning cardiac contractile function heat shock proteins coronary vascular dynamics cardioprotection 

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References

  1. 1.
    Murry CE, Jennings RB, Reimer KA. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136.PubMedCrossRefGoogle Scholar
  2. 2.
    Yellon DM, Alkhulaifi AM, Pugsley WB. 1993. Preconditioning the human myocardium. Lancet 342:276–277.PubMedCrossRefGoogle Scholar
  3. 3.
    Juggi JS, Al-Awadi F, Joseph S, Telahoun G, Prahash A. 1997. Ischemic preconditioning is not additive to preservation with hypothermia or crystalloid cardioplegia in the globally ischemic rat heart. Mol Cell Biochem 176:303–313.PubMedCrossRefGoogle Scholar
  4. 4.
    Downey JM, Liu GS, Thornton JD. 1993. Adenosine and the anti-infarct effects of preconditioning. Cardiovascular Res 27(1):3–8.CrossRefGoogle Scholar
  5. 5.
    Das DK, Engelman RM, Kimura Y. 1993. Molecular adaptation of cellular defenses following preconditioning of the heart by repeated ischemia. Cardiovasc Res 27:578–584.PubMedCrossRefGoogle Scholar
  6. 6.
    Schulz JE, Hsu AK, Groww GJ. 1996. Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circ Res 78:1100–1104.CrossRefGoogle Scholar
  7. 7.
    Baines CP, Goto M, Downey JM. 1997. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. J Moll Cell Cardiol 29:207–216.CrossRefGoogle Scholar
  8. 8.
    Marber MS, Latchman DS, Walker JM, Yellon JM. 1993. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88:1264–1272.PubMedCrossRefGoogle Scholar
  9. 9.
    Qian YZ, Shipley JB, Levasseur JE, Kukreja RC. 1998. Dissociation of heat shock proteins expression with ischemic tolerance by whole body hyperthermia in rat heart. J Mol Cell Cardiol 30(6): 1163–1172.PubMedCrossRefGoogle Scholar
  10. 10.
    Currie RW. 1987. Effects of ischemia and perfusion temperature on the synthesis of stress-induced (heat shock) proteins in iscolated and perfused rat heart. J Mol Cell Cardiol 19(8):795–808.PubMedCrossRefGoogle Scholar
  11. 11.
    Hutter MM, Sievers Re, Barbosa V, Wolfe CL. 1994. Heat shock proteins induction in rat hearts. A direct correlation between the amount of heat shock proteins induced and the degree of myocardial protection. Circulation 89:355–362.PubMedCrossRefGoogle Scholar
  12. 12.
    Knowlton AA. 1995. The role of heat shock proteins in the heart. J Mol Cell Cardiol 27:121–131.PubMedCrossRefGoogle Scholar
  13. 13.
    Amrani M, Latif N, Morrison K, Gray CC, Jayak umar J, Corbett J, Goddwin AT, Dunn MJ, Yacoub MH. 1988. Relative induction of heat shock protein in coronary endothelial cells and cardiomyocytes: implications for myocardial protection. J Thorac Cardiovasc Surg 115(l):200–209.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • J. S. Juggi
    • 1
  • E. A. R. Ghadhanfar
    • 1
  • M. Barac-Nieto
    • 1
  • S. Joseph
    • 1
  1. 1.Department of Physiology, Faculty of MedicineKuwait UniversitySafatKuwait

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