Temperature Dependence of Ischemic Preconditioning
Temperature dependence of ischemic preconditioning was evaluated in the globally ischemic model of Langendorff perfused rat heart. The results of these studies indicate that hyperthermic (42°) preconditioning offered optimal preservation of myocardial and coronary vascular functions during prolonged periods of ischemia. The cardioprotection was significantly better than at nor mo thermic or hypothermic preconditioning temperatures. The exact mechanism(s) of this protection is not clear, but the results of this study do indicate a role of HSP70, particularly the nuclear translocation of this protein during hyperthermic preconditioning.
Key wordshyperthermic ischemic preconditioning cardiac contractile function heat shock proteins coronary vascular dynamics cardioprotection
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