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Calcium Signalling During Acute Myocardial Ischemia: New Insights From Optical Mapping Techniques

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Pathophysiology of Cardiovascular Disease

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

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Summary

Acute myocardial ischemia leads to an increase in the systolic and diastolic levels of the intracellular calcium transient during the first few minutes. This overall increase is associated with beat-to-beat fluctations in the peak and trough levels of the transients—calcium transient alternans. New advances in fluorescence imaging techniques have allowed the spatial distribution of calcium transient alternans to be studied during ischemia, and to be correlated with similar imaging of the cardiac action potential. These studies provide further evidence that alternans phenomena are responsible for the genesis of ventricular fibrillation during acute ischemia, and suggest specific molecular mechanisms that could be involved.

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Author information

Authors and Affiliations

  1. Cardiovascular Divison, Stanford University School of Medicine Stanford, Ca, 94305, USA

    William T. Clusin

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  1. William T. Clusin
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Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

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© 2004 Springer Science+Business Media Dordrecht

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Clusin, W.T. (2004). Calcium Signalling During Acute Myocardial Ischemia: New Insights From Optical Mapping Techniques. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_18

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  • DOI: https://doi.org/10.1007/978-1-4615-0453-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5084-2

  • Online ISBN: 978-1-4615-0453-5

  • eBook Packages: Springer Book Archive

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