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Pathophysiology of Cardiovascular Disease pp 223–228Cite as

Cell Biology of Acute Reperfusion Injury

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Part of the book series: Progress in Experimental Cardiology ((PREC,volume 10))

Summary

In ischemic-reperfused myocardium, necrosis of cardiomyocytes may develop not only due to the ischemic conditions but also due to the specific circumstances of reperfusion. Reperfusion-induced hypercontracture is a major cause of lethal reperfusion-injury of myocardium. Hypercontracture of myofibrils is caused by reenergetisation of Ca2+-overloaded cardiomyocytes. Ca2+-overload is due to the preceding ischemic period. Upon reperfusion, Ca2+-overload leads to rapid oscillations of cytosolic Ca2+-concentration. Rapid normalisation of pH favors hypercontracture, prolonged acidosis protects against it. Inhibition of reperfusion-induced Ca2+-oscillations (inhibition of Ca2+-uptake or Ca2+-release by the sarcoplasmic reticulum; inhibition of the reverse mode of the sarcolemmal Na+/Ca2+-exchanger) or of pHi recovery (simultaneous inhibition of the Na+/H+-exchanger and the Na+/HC03 - symporter of sarcolemma) during the vulnerable phase of reperfusion can protect the ischemic-reperfused cardiomyocyte against reperfusion injury.

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Author information

Authors and Affiliations

  1. Physiological Institute, Justus Liebig University, Aulweg 129, D-35392, Giessen, Germany

    Claudia Schäfer & Hans-Michael Piper

Authors
  1. Claudia Schäfer
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  2. Hans-Michael Piper
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Corresponding author

Correspondence to Claudia Schäfer .

Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

  2. Philipps University of Marburg, Marburg, Germany

    Heinz Rupp PhD (Professor of Medicine) (Professor of Medicine)

  3. Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Aubie Angel MD (Professor of Internal Medicine) (Professor of Internal Medicine)

  4. Division of Stroke & Vascular Disease St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

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© 2004 Springer Science+Business Media Dordrecht

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Schäfer, C., Piper, HM. (2004). Cell Biology of Acute Reperfusion Injury. In: Dhalla, N.S., Rupp, H., Angel, A., Pierce, G.N. (eds) Pathophysiology of Cardiovascular Disease. Progress in Experimental Cardiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0453-5_16

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  • DOI: https://doi.org/10.1007/978-1-4615-0453-5_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5084-2

  • Online ISBN: 978-1-4615-0453-5

  • eBook Packages: Springer Book Archive

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