Mechanisms of Immune Dysfunction in Renal Cell Carcinoma

  • Ithaar H. Derweesh
  • Charles S. Tannenbaum
  • Patricia A. Rayman
  • James H. Finke
Part of the Cancer Treatment and Research book series (CTAR, volume 116)


The immunologic control of carcinogenesis was first demonstrated by Gross in 1943,1 who made the observation that inbred mice could be immunized against tumor transplants from syngeneic animals. In 1970, the concept of “immune surveillance” was developed by Burnet2,who proposed that cancers express unique antigens that would allow their detection by the host’s immune system. Subsequent discovery of T cell subsets, TCR complex, antigen presentation, MHC restriction and molecular approaches to identify antigens have contributed to our understanding of T cell immunity to tumors


Renal Cell Carcinoma Major Histocompatibility Complex Major Histocompatibility Complex Class Costimulatory Molecule Metastatic Renal Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Ithaar H. Derweesh
    • 1
    • 3
  • Charles S. Tannenbaum
    • 1
  • Patricia A. Rayman
    • 1
  • James H. Finke
    • 1
    • 2
    • 3
  1. 1.Department of ImmunologyLerner Research InstituteUSA
  2. 2.Experimental TherapeuticsUSA
  3. 3.Glickman Urological InstituteCleveland Clinic FoundationClevelandUSA

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