Kidney Cancer pp 227-238 | Cite as

Novel Therapies for Renal Cell Carcinoma

  • Samira Syed
  • Anthony W. Tolcher
Part of the Cancer Treatment and Research book series (CTAR, volume 116)


The treatment of advanced renal cell carcinoma presents a daunting challenge to medical, surgical and radiation oncologists. Although patients with localized renal cell carcinoma can be effectively treated by surgery with a 5 year survival of up to 88%, the treatment options are limited for patients with advanced disease with the 5 year survival rate under 10%.12Furthermore, systemic chemotherapeutic agents have had little impact on the natural history of this disease. A comprehensive review by Yagodaet at 3 encompassed 4542 patients enrolled in 83 clinical trials published from 1983 through 1993. Among the 4093 evaluable patients, a 6% overall response rate was determined which was comprised of 53 (1.3%) complete responses and 192 (4.7%) partial responses. This dismal level of antitumor activity is comparable to the reported rate of spontaneous objective responses observed for placebo treated patients entered in a randomized study.4


Vascular Endothelial Growth Factor Epidermal Growth Factor Receptor Renal Cell Carcinoma Clin Oncol Metastatic Renal Cell Carcinoma 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Samira Syed
    • 1
  • Anthony W. Tolcher
    • 2
  1. 1.Division of Medical OncologyUniversity of Texas Health Science Center at San AntonioUSA
  2. 2.Associate Director Clinical Research, Institute for Drug Development, Cancer Therapy and Research Center and Associate Clinical Professor of MedicineUniversity of Texas Health Science Center at San AntonioUSA

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