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Epidemiology and Control of Pseudomonas Aeruginosa Infections in the Intensive Care Unit

North American Perspective

  • Chapter
Severe Infections Caused by Pseudomonas Aeruginosa

Part of the book series: Perspectives on Critical Care Infectious Diseases ((CCID,volume 7))

Abstract

Healthcare-associated infections (HAIs) are infections that are not present or incubating at the time of healthcare (e.g., hospital, long-term care, etc.) admission or encounter (1,2). Although HAIs can become clinically apparent during or after hospitalization, the majority become manifest during hospitalization. This is particularly true of HAIs in intensive care unit (ICU) patients, the population in the healthcare delivery system with the highest rates of HAIs. ICU patients are the most severely ill and have the highest rate of use of invasive devices or procedures. Most HAIs are associated with invasive devices, e.g., central venous catheters (CVCs), mechanical ventilation, or urinary catheterization, or procedures, particularly surgical procedures.

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References

  1. Garner J, Jarvis WR, Emori G, Horan TC, and Hughes JM. The Centers for Disease Control definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16:128–140.

    Article  PubMed  CAS  Google Scholar 

  2. Horan TC. Gaynes RP. Martone WJ. Jarvis WR. Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control & Hosp Epidemiol 1992; 13:606–608.

    Article  CAS  Google Scholar 

  3. Horan TC. Emori TG. Definitions of key terms used in the NNIS System. Am J Infect Control 1997; 25:112–116.

    Article  PubMed  CAS  Google Scholar 

  4. Emori TG, Culver DH, Horan TC, Jarvis WR, White JW, Banerjee SN, White JW, Edwards JR, Martone WJ, Gaynes RP, Olsen DR and Hughes JM. National Nosocomial Infections Surveillance System (NNIS): Description of methodology and surveillance components. Am J Infect Control 1991; 19:19–36.

    Article  PubMed  CAS  Google Scholar 

  5. Jarvis WR, Edwards JR, Culver DH, Hughes JM, Horan T, Emori TG, Banerjee SN, Tolson J, Henderson T, Gaynes RP, Martone WJ, and the National Nosocomial Infections Surveillance System. Nosocomial infection rates in adult and pediatric intensive care units. Am J Med 1991; 91:185S–191S.

    Article  PubMed  CAS  Google Scholar 

  6. National Nosocomial Infections Surveillance (NNIS)System Report. Data summary from January 1992-June 2001, Issued August 2001. Am J Infect Control 2001; 29:404–421.

    Article  Google Scholar 

  7. Archibald L. Phillips L. Monnet D. McGowan JE Jr. Tenover F. Gaynes R. Antimicrobial resistance in isolates from inpatients and outpatients in the United States: increasing importance of the intensive care unit. Clin Infect Dis. 1997; 24:211–21.

    Article  PubMed  CAS  Google Scholar 

  8. Fridkin SK. Steward CD. Edwards JR. Pryor ER.McGowanJE Jr. ArchibaldLK. Gaynes RP. Tenover FC. Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: project ICARE phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) hospitals. Clin Infect Dis. 1999; 29:245–252.

    Article  PubMed  CAS  Google Scholar 

  9. Monnet DL. Archibald LK. Phillips L. Tenover FC. McGowan JE Jr. Gaynes RP.Antimicrobial use and resistance in eight US hospitals: complexities of analysis and modeling. Intensive Care Antimicrobial Resistance Epidemiology Project and National Nosocomial Infections Surveillance System Hospitals. Infect Control & Hosp Epidemiol 1998; 19:388–394.

    Article  CAS  Google Scholar 

  10. Richards MJ, Edwards JR, Culver DIA, Gaynes RP. Nosocomial infections in medical intensive care units in the United States. Crit Care Med 1999; 27:887–892.

    Article  PubMed  CAS  Google Scholar 

  11. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in coronary care units in the United States. Am J Cardiol 1998; 82:789–793.

    Article  PubMed  CAS  Google Scholar 

  12. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in pediatric intensive care units in the United States. Pediatrics 1999; 103:e39.

    Google Scholar 

  13. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in medical-surgical units in the United States. Infect Control and Hosp Epidemiol 2000; 21:510–515.

    Article  CAS  Google Scholar 

  14. Pittet D. Nosocomial Bloodstrem Infections. In: Wenzel RP, ed. Prevention and Control of Nosocomial Infections. 3“Ied. Baltimore: Williams and Wilkins, 1977:711–769.

    Google Scholar 

  15. Pittet D, TararaD, Wenzel RP. Nosocomialbloodstream infection in critically ill patients: Excess length of stay, extra costs, and attributable mortality. JAMA 1994; 271:1598–1601.

    Article  PubMed  CAS  Google Scholar 

  16. Farr BM. Nosocomial infections related to use of intravascular devices inserted for short-term vascular access. Chapter 11, In Hospital Epidemiology and Infection Control.Second Edition, CG Mayhall, Editor, Lippincott Williams and Wilkins Philadelphia, PA,1999.

    Google Scholar 

  17. Jones RN, Marshall SA, Pfaller MA, Wilke WW, Hollis RJ, Erwin ME, Edmond MB, Wenzel RP, and the SCOPE Hospital Study Group. Nosocomial enterococcal blood stream infections in the SCOPE Program: Antimicrobial resistance, species occurrence, molecular testing results, and laboratory testing accuracy. Diagn Microbiol Infect Dis 1997; 29:95–102.

    Article  PubMed  CAS  Google Scholar 

  18. Pfaller MA, Jones RN, Doem GV, Kugler K, and The SENTRY ParticipantsGroup. Bacterial pathogens isolated from patients with bloodstream infection: Frequencies of occurrence and antimicrobial susceptibility program (United States and Canada, 1997). Antimicrob Agents Chemother 1998; 42:1762–1770.

    CAS  Google Scholar 

  19. Nosocomial Pneumonia. WR Jarvis, Editor. Marcel Dekker, Inc., New York, 2000.

    Google Scholar 

  20. Rello J, Jubert P, Valles J et al. Evaluation of outcome for intubated patients with pneumonia due to Pseudomonas aeruginosa. Clin Infect Dis 1996; 23:973–978.

    Article  PubMed  CAS  Google Scholar 

  21. Fagon JY, Chastre J, Domart Y, et al. Nosocomial pneumonia in patients receiving continuous mechanical ventilation: Prospective analysis of 52 episodes with use of a protected brush and quantitative culture technique. Am Rev Resp Dis 1989; 139:877884.

    PubMed  CAS  Google Scholar 

  22. Rello J, Ausina V, Ricart M, Castella J,Prats G. Impact of previous antimicrobial therapy on the etiology of ventilator-associated pneumonia. Chest 1993; 104:1230–1235.

    Article  PubMed  CAS  Google Scholar 

  23. Burke JP and Zavasky DM. Nosocomial urinary tract infections. Chapterl3, In Hospital Epidemiology and Infection Control. Second Edition, CG Mayhall, Editor, Lippincott Williams and Wilkins, Philadelphia, PA, 1999.

    Google Scholar 

  24. Garibaldi RA, Burke JP, Dickman ML, Smith CB. Factors predisposing to bacturiuria during indwelling urethral catheterization. N Engl J Med 1974; 291:215–219.

    Article  PubMed  CAS  Google Scholar 

  25. Platt R, Polk BF, Murdock B, Rosner B. Risk factors for nosocomial urinary tract infection. Am J Epidemiol 1986; 124:977–985.

    PubMed  CAS  Google Scholar 

  26. Marrie TJ, Major H, Gurwith M, Ronald AR, Harding GK, Forrest G, Forsythe W. Prolonged outbreak of nosocomial urinary tract infection with a single strain of Pseudomonas aeruginosa. Can Med Assoc J 1978; 119:593–596.

    PubMed  CAS  Google Scholar 

  27. File, TM, Jr, Tan JS, Thompson RB, Stephens C, Thompson P. An outbreak of Pseudomonas aeruginosa ventilator-associated respiratory infections due to contaminated food coloring dye B. Further evidence of the significance of gastric colonization preceding nosocomial pneumonia. Infect Control and Hosp Epidemiol 1955; 16:417–418.

    Article  Google Scholar 

  28. Widmer AF, Wenzel RP, Trilla A, Bale MJ, Jones RN, Doebbeling BN. Outbreak of Pseudomonas aeruginosa infections in a surgical intensive care unit: Probable transmission via hands of a health care worker. Clin Infect Dis 1993; 16:372–376.

    Article  PubMed  CAS  Google Scholar 

  29. Becks VE. Lorenzoni NM. .Pseudomonas aeruginosa outbreak in a neonatal intensive care unit: A possible link to contaminated hand lotion. Am J Infect Control 1995; 23:396–398.

    Article  PubMed  CAS  Google Scholar 

  30. Archibald LK, Ramos M, Arduino MJ, Aguero SM, Deseda C, Banerjee S, Jarvis WR.Enterobacter cloacae and Pseudomonas aeruginosa polymicrobial bloodstream infections traced to extrinsic contamination of a dextrose multidose vial. J Pediatr 1998; 133:640–644.

    Article  PubMed  CAS  Google Scholar 

  31. Trick WE, Kioski CM, Howard KM, Cage GD,Tokars JI, Yen BM, Jarvis WR. Outbreak of Pseudomonas aeruginosa ventriculitis among patients in a neurosurgical intensive care unit. Infect Control & Hosp Epidemiol 2000; 21:204–208.

    Article  CAS  Google Scholar 

  32. Foca M, Jakob K, Whittier S, Della Latta P. Factor S, Rubenstein D, Saiman L. Endemic Pseudomonas aeruginosa infection in a neonatal intensive care unit. N Engl J Med 2000; 343:695–700.

    Article  PubMed  CAS  Google Scholar 

  33. Sader HS, Pignatari AC, Leme IL, Burattini MN, Tancresi R, Hollis RJ, Jones RN. Epidemiologic typing of multiply drug-resistant Pseudomonas aeruginosa isolated from an outbreak in an intensive care unit. Diagn Microbiol Infect Dis 1993; 17:13–18.

    Article  PubMed  CAS  Google Scholar 

  34. Jumaa P, Chattopadhyay B. Outbreak of gentamicin, ciprofloxacin-resistant Pseudomonas aeruginosa in an intensive care unit, traced to contaminated quivers. J Hosp Infect 1994; 28:209–218.

    Article  PubMed  CAS  Google Scholar 

  35. Kerr JR. Moore JE, Curran MD, Graham R, Webb CH, Lowry KG, Murphy PG, Wilson TS, Ferguson WP. Investigation of a nosocomial outbreak of Pseudomonas aeruginosa pneumonia in an intensive care unit by random amplification of polymorphic DNA assay. J Hosp Infect 1995; 30:125–131.

    Article  PubMed  CAS  Google Scholar 

  36. Garland SM, Mackay S, Tabrizi S, Jacobs S.Pseudomonas aeruginosa outbreak associated with a contaminated blood-gas analyser in a meonatal intensive care unit. J Hosp Infect 1996; 33:145–151.

    Article  PubMed  CAS  Google Scholar 

  37. Muyldermans G, de Smet F, Pierard D, Steenssens L, Stevens D, Bougatef A, Lauwers S. Neonatal infections with Pseudomonas aeruginosa associated with a water-bath used to thaw fresh frozen plasma. J Hosp Infect 1998; 39:309–314.

    Article  PubMed  CAS  Google Scholar 

  38. Bert F, Maubec E, Bruneau B, Berry P, Lambert-Zechovsky N. Multi-resistant Pseudomonas aeruginosa outbreak associated with contaminated tap water in a neurosurgery intensive care unit. J Hosp Infect 1998; 39:53–62.

    Article  PubMed  CAS  Google Scholar 

  39. Lyytikainen 0, Golovanova V, Kolho E, Ruutu P, Sivonen A, Tiittanen L, Hakanen M. Vuopio-Varkila J. Outbreak caused by tobramycin-resistant Pseudomonas aeruginosa in a bone marrow transplantation unit. Scand J Infect Dis 2001; 33:445–449.

    Article  PubMed  CAS  Google Scholar 

  40. Luzzaro F, Mantengoli E, Perilli M, Lombardi G, Orlandi V, Orsatti A, Amicosante G, Rossolini GM, Toniolo A. Dynamics of a nosocomial outbreak of multidrug-resistant Pseudomonas aeruginosa producing the PER-1 extended-spectrum beta-lactamase. J Clin Micro 2001; 39:1865–1870.

    Article  CAS  Google Scholar 

  41. Pitten FA, Panzig B, Schroder G, Tietze K, Kramer A. Transmission of a multiresistant Pseudomonas aeruginosa strain at a German university hospital. J Hosp Infect 2001; 47:125–130.

    Article  PubMed  CAS  Google Scholar 

  42. Trautmann M, Michalsky T, Wiedeck H, Radosavljevic V, Ruhnke M. Tap water colonization with Pseudomonas aeruginosa in a surgial intensive care Unit (ICU) and relation to Pseudomonas infections of ICU patients. Infect Control and Hosp Epidemiol 2001; 22:49–52.

    Article  CAS  Google Scholar 

  43. Pellegrino FL, Teixeira LM, Carvalho MMG, Aranha Nouer S, Pinto De Oliveira M, Mello Sampaio JL, DAvila Freitas A, Ferreira AL, Amorim EEL, Riley LW, Moreira BM. Occurrence of a multidrug-resistnat Pseudomonas aeruginosa clone in different hospitals in Rio De Janeiro, Brazil. J Clin Microbiol 2002; 40:2420–2424.

    Article  PubMed  CAS  Google Scholar 

  44. Heyland DK, Cook DJ, Griffith L, Keenan SP, Brun-Buisson C. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group. Am J Resp Crit Care Med 1999; 159:1249–1256.

    PubMed  CAS  Google Scholar 

  45. Kollef MH, Silver P, Murphy DM, Trovillion E. The effect of late-onset ventilator-associated pneumonia in determining patient mortality. Chest 1995; 108:1655–1662.

    Article  PubMed  CAS  Google Scholar 

  46. Niederman MS. Impact of antibiotic resistance on clinical outcomes and the cost of care. Crit Care Med 2001; 29:N114–N120.

    Article  PubMed  CAS  Google Scholar 

  47. Manian FA, Meyer L, Jenne J, Owen A, Taff T. Loss of antimicrobial susceptibility in aerobic gram-negative bacilli repeatedly isolated from patients in intensive care units. Infect Control and Hosp Epidemiol 1996; 17:222–226.

    Article  CAS  Google Scholar 

  48. Gruson D, Hilbert G, Vargas F, Valentino R, Bebear C, Allery A, Bebear C, GbikpiBenissan G, Cardinaud JP. Rotation and restricted use of antibiotics in a medical intensive care unit. Impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria. Am J RespCrit Care Med 2000; 162:837–843.

    CAS  Google Scholar 

  49. Yehuda C, Troillet N, Karchmer AW, Samore MEI. Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa. Arch Intern Med 1999; 159:1127–1132.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    William R. Jarvis M.D

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  1. William R. Jarvis M.D
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Editors and Affiliations

  1. Departments of Microbiology/Immunology and Medicine, Northwestern University, Chicago, IL, USA

    Alan R. Hauser M.D., Ph.D.

  2. Critical Care Department, Joan XXIII University Hospital University Rovira & Virgili, Tarragona, Spain

    Jordi Rello M.D., Ph.D.

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Jarvis, W.R. (2003). Epidemiology and Control of Pseudomonas Aeruginosa Infections in the Intensive Care Unit. In: Hauser, A.R., Rello, J. (eds) Severe Infections Caused by Pseudomonas Aeruginosa . Perspectives on Critical Care Infectious Diseases, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0433-7_10

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  • DOI: https://doi.org/10.1007/978-1-4615-0433-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5074-3

  • Online ISBN: 978-1-4615-0433-7

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