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Ca2+—Dependent Signaling Pathways Through Calcineurin and Ca2+ Calmodulin—Dependent Protein Kinase in Development of Cardiac Hypertrophy

  • Chapter
Signal Transduction and Cardiac Hypertrophy

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 7))

Summary

Cardiac hypertrophy is induced by a variety of cardiovascular diseases such as hypertension, valvular diseases, myocardial infarction, cardiomyopathy, and endocrine disorders. Although cardiac hypertrophy may be initially a beneficial response that normalizes wall stress and maintains normal cardiac function, prolonged hypertrophy becomes a leading cause of heart failure and sudden death. A number of studies have elucidated molecules responsible to the development of cardiac hypertrophy, including protein kinase C (PKC), protein kinase A (PKA), Raf-1 kinase, mitogen-activated protein (MAP) kinase family, and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) family, Ras, and Rho family. It has been reported that Ca2+ regulates a number of cellular processes including cardiac hypertrophy. Since most hypertrophic signaling pathways are associated with an increase in intracellular Ca2+, Ca2+-dependent signaling pathways may be critical targets for therapies designed to prevent the progression of cardiac hypertrophy. Recently, a Ca2+/calmodulin-dependent protein kinase, and a Ca2+/calmodulin-dependent protein phosphatase, calcineurin, have attracted much attention as critical molecules that induce cardiac hypertrophy. In this review, we summarize the Ca2+-dependent signaling pathways through Ca2+/calmodulin-dependent protein kinase and calcineurin in cardiac hypertrophy.

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Authors and Affiliations

  1. Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Hiroyuki Takano, Yunzeng Zou, Hiroshi Akazawa, Toshio Nagai, Miho Mizukami, Haruhiro Toko & Issei Komuro MD, PhD

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  1. Hiroyuki Takano
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  2. Yunzeng Zou
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  3. Hiroshi Akazawa
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  4. Toshio Nagai
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  5. Miho Mizukami
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  6. Haruhiro Toko
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  7. Issei Komuro MD, PhD
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Correspondence to Issei Komuro MD, PhD .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director), Larry V. Hryshko PhD (Associate Professor), Elissavet Kardami PhD (Professor) & Pawan K. Singal PhD, DSc (Professor) (Distinguished Professor and Director),  (Associate Professor),  (Professor) &  (Professor)

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Takano, H. et al. (2003). Ca2+—Dependent Signaling Pathways Through Calcineurin and Ca2+ Calmodulin—Dependent Protein Kinase in Development of Cardiac Hypertrophy. In: Dhalla, N.S., Hryshko, L.V., Kardami, E., Singal, P.K. (eds) Signal Transduction and Cardiac Hypertrophy. Progress in Experimental Cardiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0347-7_7

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  • DOI: https://doi.org/10.1007/978-1-4615-0347-7_7

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