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Role of Renin-Angiotensin System in Phospholipase C-Mediated Signaling in Congestive Heart Failure

  • Chapter
Book cover Signal Transduction and Cardiac Hypertrophy

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 7))

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Summary

The molecular events underlying the cardiac contractile dysfunction in congestive heart failure are not fully understood. Although different drugs such as angiotensin converting enzyme inhibitors and angiotensin receptor antagonist have been shown to improve cardiac function, the mechanisms of these agents in the failing heart remain largely unexplored. Since phospholipase C (PLC) is known to generate signaling molecules which are critical in increasing contractile force development, it is likely that changes in PLC may be responsible in altering cardiac contractile force in congestive heart failure. This article reviews the role of the renin angiotensin system in PLC signal transduction mechanisms as well as discussion of the potential of such signaling events as additional targets for the action of angiotensin converting enzyme inhibitors and angiotensin receptor antagonists.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre (R3020), 351 Tache Avenue, Winnipeg, R2H 2A6, Manitoba, Canada

    Dr. Paramjit S. Tappia, Nina Aroutiounova & Naranjan S. Dhalla

  2. Departments of Human Nutritional Sciences and Physiology, Faculties of Human Ecology and Medicine, University of Manitoba, Winnipeg, Canada

    Dr. Paramjit S. Tappia, Nina Aroutiounova & Naranjan S. Dhalla

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  1. Dr. Paramjit S. Tappia
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Correspondence to Paramjit S. Tappia .

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  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director), Larry V. Hryshko PhD (Associate Professor), Elissavet Kardami PhD (Professor) & Pawan K. Singal PhD, DSc (Professor) (Distinguished Professor and Director),  (Associate Professor),  (Professor) &  (Professor)

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Tappia, P.S., Aroutiounova, N., Dhalla, N.S. (2003). Role of Renin-Angiotensin System in Phospholipase C-Mediated Signaling in Congestive Heart Failure. In: Dhalla, N.S., Hryshko, L.V., Kardami, E., Singal, P.K. (eds) Signal Transduction and Cardiac Hypertrophy. Progress in Experimental Cardiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0347-7_24

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