Summary
The Na+/HCO3 - cotransport (NBC) contributes to 40–50% of total acid extrusion in ventricular myocardium. There is, at least, one electrogenic isoform of the NBC in the heart, with a stoichiometry ratio of 2HCO3 -: 1Na+. This cardiac electrogenic NBC abbreviates the action potential and hyperpolarizes the resting membrane potential, being these effects usually masked by the wide use of non-bicarbonate solutions in the electrophysiological recordings. The activation of the electrogenic NBC alkalinazes the cell after increases in heart rate, suggesting a role of this transporter in the compensation for the enhanced proton production induced by the acceleration of cell metabolism. The role of NBC in ischemic-reperfusion injury and heart failure remains to be determined. However, there is increasing evidence that involves this transporter as one of the Na+-Loading mechanisms during reperfusion.
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© 2003 Springer Science+Business Media New York
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Aiello, E.A. (2003). Role of the Electrogenic Na+/HCO3 - Symport in the Heart. In: Dhalla, N.S., Hryshko, L.V., Kardami, E., Singal, P.K. (eds) Signal Transduction and Cardiac Hypertrophy. Progress in Experimental Cardiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0347-7_11
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DOI: https://doi.org/10.1007/978-1-4615-0347-7_11
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