Abstract
Genomic and proteomic information is transforming all fields of cancer research. The increased understanding of the genomics and molecular pathology of cancer also provides a framework for designing new therapeutic strategies. The majority of the genes in most genomes are still of unknown function, and many studies on proteomics are attempting to fill this knowledge gap. Since biochemical information flows from DNA to RNA to protein to function, the role of each gene product in metabolism clearly needs to be studied. A recent theoretical study by ter Kuile and Westerhoff (2001) using the methods of Metabolic Control Analysis demonstrated that there is no general quantitative relationship between mRNA levels and function. Thus a comprehensive study of many metabolites together could become invaluable, and several approaches to this are being developed including metabolite target analysis, metabolite profiling, metabolomics and metabolic fingerprinting as described elsewhere in this book (Fiehn, Chapter 11, see also Fiehn, 2001).
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Chung, YL., Stubbs, M., Griffiths, J.R. (2003). Metabolic Profiling in Tumors by In Vivo and In Vitro NMR Spectroscopy. In: Harrigan, G.G., Goodacre, R. (eds) Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0333-0_5
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