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Dynamic Profiling and Canonical Modeling

Powerful Partners in Metabolic Pathway Identification
  • Eberhard O. Voit
  • Jonas Almeida

Abstract

Biological research attempts to answer the question: How do organisms function? Once we can answer this question, we can explain our natural surroundings and begin to change them in a targeted fashion that offers us benefit, may it be in medicine, agriculture, biotechnology, or a responsible exploitation of the environment. The challenge is that we were not provided with a blueprint of the inner workings of organisms. We have very many observational data, but they are almost always mere snapshots of some parts of some organisms under some more or less controlled conditions. Often these snapshots are clustered in some interesting corner of the biological universe, but more often they are separated by gaping holes in our knowledge. Our task is then to interpolate between rather scarce data in order to construct a picture that matches the observations and, more interestingly, explains what lies between and beyond.

Keywords

Genetic Algorithm Metabolic Profile Metabolic Network Mixed Integer Linear Programming Kinetic Order 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Eberhard O. Voit
    • 1
  • Jonas Almeida
    • 1
    • 2
  1. 1.Department of Biometry and EpidemiologyGermany
  2. 2.Department of Biochemistry and Molecular BiologyMedical University of South CarolinaCharlestonUSA

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