Cytokine-Elicited Sensitization

Neuroendocrine, Neurotransmitter and Behavioral Responses
  • Shawn Hayley
  • Zul Merali
  • Hymie Anisman
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 7)


In addition to having short-term effects, stressors may proactively augment the response to subsequently encountered insults (sensitization) and may thus have protracted repercussions on health risk. It is known, for instance, that stressors alter central neurotransmitter activity and activate hypothalamic-pituitary-adrenal (HPA) axis activity (1). Upon later encounters with aversive stimuli, even of diminished severity, such neurochemical alterations may be exaggerated and more readily induced (2), and may come to impact on a variety of pathological states, including those related to mood disorders, cardiovascular illness, and immune processes (3,4).


Locus Coeruleus Medial Prefrontal Cortex Paraventricular Nucleus Median Eminence Plasma Corticosterone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Shawn Hayley
    • 1
  • Zul Merali
    • 2
  • Hymie Anisman
    • 1
  1. 1.Institute of NeuroscienceCarleton UniversityCanada
  2. 2.School of Psychology and Department of Cellular and Molecular MedicineUniversity of OttawaOttawaCanada

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