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Cytokine-Elicited Sensitization

Neuroendocrine, Neurotransmitter and Behavioral Responses

  • Chapter
Cytokines and Mental Health

Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 7))

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Abstract

In addition to having short-term effects, stressors may proactively augment the response to subsequently encountered insults (sensitization) and may thus have protracted repercussions on health risk. It is known, for instance, that stressors alter central neurotransmitter activity and activate hypothalamic-pituitary-adrenal (HPA) axis activity (1). Upon later encounters with aversive stimuli, even of diminished severity, such neurochemical alterations may be exaggerated and more readily induced (2), and may come to impact on a variety of pathological states, including those related to mood disorders, cardiovascular illness, and immune processes (3,4).

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  1. Institute of Neuroscience, Carleton University, Canada

    Shawn Hayley & Hymie Anisman

  2. School of Psychology and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada

    Zul Merali

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  1. University of Michigan Health System, Ann Arbor, USA

    Ziad Kronfol

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Hayley, S., Merali, Z., Anisman, H. (2003). Cytokine-Elicited Sensitization. In: Kronfol, Z. (eds) Cytokines and Mental Health. Neurobiological Foundation of Aberrant Behaviors, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0323-1_11

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