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Correlation between the extent of coronary atherosclerosis and lipid profile

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Vascular Biochemistry

Abstract

Increased concentration of low density lipoprotein (LDL) cholesterol or decreased level of high density lipoprotein (HDL) cholesterol are important risk factors for coronary atherosclerosis. However, an independent association of triglycerides (TG) with atherosclerosis is uncertain.

The aim of this prospective study was to evaluate the relationship between serum lipid levels and the extent of coronary atherosclerosis in patients with suspected coronary artery disease (CAD) and no previous myocardial infarction who were not treated with lipids lowering therapy or low-lipid diet.

The study was conducted in 141 patients (53.6 ± 7.8 years old; 32 female) who underwent a routine coronary angiography for CAD diagnosis. A modified angiographic Gensini Score (GS) was used to reflect the extent of coronary atherosclerosis. Fasting serum lipid concentrations were determined using cholesterol esterase/peroxidase (CHOD/PAP) enzymatic method for total cholesterol and its fractions and lipase glycerol kinase (GPO/PAP) enzymatic method TG evaluation. The association of Gensini Score with variables characterising lipid profile was analysed with the use of Pearson correlation (r co-efficient; p value).

GS was positively correlated with total cholesterol (r = 0.404; p < 0.001), LDL cholesterol (r = 0.484; p < 0.001) and TG (r = 0.235; p = 0.005). There was a negative correlation between Gensini Score and HDL cholesterol (r = -0.396; p < 0.001).

In angina pectoris patients with no previous myocardial infarction, the extent of coronary atherosclerosis is positively correlated with pro-atherogenic lipids, i.e. total cholesterol, LDL cholesterol and TG and negatively correlated with antiatherogenic HDL cholesterol. (Mol Cell Biochem 246: 25-30,2003)

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Authors and Affiliations

  1. Department of Cardiology, Municipal Hospital in Kalisz, Kalisz, Poland

    Janusz Tarchalski

  2. Department of Cardiology - Intensive Therapy, Karol Marcinkowski’s University School of Medical Sciences, Poznañ, Poland

    Przemysław Guzik & Henryk Wysocki

Authors
  1. Janusz Tarchalski
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  2. Przemysław Guzik
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  3. Henryk Wysocki
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Editors and Affiliations

  1. Research Center, St. Boniface General Hospital, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Peter Zahradka

  2. Institute of Cardiovascular Sciences, St. Boniface General Hospital, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Jeffrey Wigle

  3. Division of Stroke & Vascular Disease, St. Boniface General Hospital Research Center, Canada

    Grant N. Pierce

  4. Faculty of Medicine, University of Manitoba, R2H 2A6, Winnipeg, Manitoba, Canada

    Grant N. Pierce

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Tarchalski, J., Guzik, P., Wysocki, H. (2003). Correlation between the extent of coronary atherosclerosis and lipid profile. In: Zahradka, P., Wigle, J., Pierce, G.N. (eds) Vascular Biochemistry. Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0298-2_4

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  • DOI: https://doi.org/10.1007/978-1-4615-0298-2_4

  • Publisher Name: Springer, Boston, MA

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