Abstract
Life is sustained by the continuous conversion of biochemical energy to mechanical energy, which is required to maintain the various functions of living organisms. This wide range of energetic activities depends on rotary and linear molecular (protein) motors of nanometer scale, which propel (bacteria, sperms), transport (messengers in neural network, cell division) generate high-energy metabolites (ATPsynthase) and perpetuate motion (muscle shortening).
This study relates to the linear molecular motor, myosin, which is energized by ATP (adenosine triphosphate) hydrolysis, and actuates muscle filament contraction. The actin-myosin filaments make up the intracellular contractile apparatus, the sarcomeres, and their relative motion, sliding one over the other, determines the functional characteristics of the contracting heart muscle.
The study explores the relationship between the biochemical energy consumption and the mechanical output of the motor units of the heart muscle. The analysis is based on coupling motor unit dynamics with free calcium binding kinetics, which regulates the motor unit activity. The calcium binds to the regulatory proteins of the contractile filaments and regulates the number of activated myosin motor units. The analysis quantifies the conversion efficiency and the determinants of the muscle’s economy. The intracellular interplay between efficiency and economy determines the adaptability of the heart muscle to the prevailing loading conditions. The analysis highlights the intracellular mechanisms and the adaptive processes that allow the heart to optimize its function under various loading conditions.
Whereas the thermodynamic efficiency of the overall metabolic transformation from biochemical energy to mechanical energy of the whole organ is 25–35%, the efficiency of energy transduction from ATP to mechanical energy ranges between 50 to 70%. This high efficiency of energy conversion reflects the extremely high efficiency of the myosin motor unit, wherein the ATPase enzyme is instrumental in ATP hydrolysis ATP + H2O ↔ ADP+P reaction and the production of mechanical energy. Finally, we discuss the notion that man is challenged by nature’s functional design in his pursuit of new horizons.
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References
Woledge R.C., Reilly P.J. Molar Enthalpy Change to Hydrolysis of Phosphocreatine under Conditions in Muscle Cell. Biophys. J. 1988; 54: 97–104.
Wang H., Oster G. Energy Tranduction in the F, Motor of ATP Synthase. Nature 1998; 396: 279–282.
Oster G., Wang H. ATP Synthase: Two Motors, Two Fuels. Structure 1999; 7 (4): 67–72.
Fisher M.E., Kolomeisky A.B. The Force Exerted by a Molecular Motor. Proc. Nat. Acad. Sci. USA. 96:6597–6602, 1999.
Eisenberg E., Hill T.L. Muscle Contraction and Free Energy Transduction in Biological System. Science. 1985; 227: 999–1006.
Landesberg A. End Systolic Pressure-Volume Relation Based on the Intracellular Control of Contraction. Am J Physiol. 1996; 270 (Heart Circ. Physiol. 39):H338–H349.
Landesberg A. Intracellular Mechanism in Control of Myocardial Mechanics and Energetics. In Analytical and Quantitative Cardiology: From Genetics to Function. S. Sideman and R. Beyar, eds.NY Plenum. 1997; 430: 75–87.
Landesberg A., Sideman S. Coupling Calcium Binding to Troponin-C and Xb Cycling Kinetics in Skinned Cardiac Cells. Am J. Physiol. 1994; 266 (Heart Circ. Physiol. 35): H1261–H1271.
Landesberg A., Sideman S. Mechanical Regulation in the Cardiac Muscle by Coupling Calcium Binding to Troponin-C and Xb Cycling. A Dynamic Model. Am. J. Physiol. 1994; 267 (Heart Circ Physiol 36): H779–H795.
Landesberg A., Sideman S. Regulation of Energy Consumption in the Cardiac Muscle: Analysis of Isometric Contractions. A Dynamic Model. Am. J. Phsyiol. 1999; 276: H998–H1011.
Landesberg A., Sideman S. Force Velocity Relationship and Biochemical to Mechanical Energy Conversion by the Sarcomere. Am. J. Physiol., in press, 2000.
Landesberg A., ter Keurs HED.T. Regulation of Force Output by the Velocity of Sarcomere Shortening in Rat Cardiac Trabecular Circulation. 1997; 96 (8): 2906.
Landesberg A., ter Keurs HEDJ. Crossbridge Dynamics during Shortening is Determined by Two Kinetic Components. J. Mol. Cell. Cardiol. 1998; 30: A171.
Landesberg A., Liu P., Lichtenstein O., Shofti R., Beyar R., Sideman S. Effect of Ejection Velocity on Pressure Generation in the Heart. In situ canine studies. VIII Mediterranean Conf. on Medical and Biological Engineering and Computing, Limassol, Cyprus, pp. 1–5, 1998.
Beyar R., Sideman S. A Computer Study of the Left Ventricular Performance Based on Fiber Structure, Sarcomere Dynamics, and Transmural Electrical Propagation Velocity. Circ. Res. 1984; 55: 358–75.
Campbell K.B., Shroff S.G., Kirkpatrick R.D. Short Time Scale Left Ventricle Systolic Dynamics. Circ. Res. 1991; 68:1532–48.
Sagawa K., Maughan L., Suga H., Sunagawa K. Cardiac Contraction and the Pressure-Volume Relationship. London, UK: Oxford Univ Press, 1988.
Suga H. Ventricular Energetics. Physiol. Rev. 1990; 70:247–277.
Hisano G., Cooper IV. Correlation of Force-Length Area with Oxygen Consumption in Ferret Papillary Muscle. Circ. Res. 1987; 61:318–28.
Landesberg A., Zhang Y.M., ter Keurs HEDJ. Regulation of Tension-Length Free Calcium Relationship in the Skinned Rat Trabeculae. J. Biophysics, in press 2000.
Peterson J.N., Hunber W.C., Berman M.R. Estimated Time Course of Calcium Bound to Troponin-c during Relaxation in Isolated Cardiac Muscle. Am. J. Cardiol. 1977; 40: 748–53.
Landesberg A., Sideman S. Calcium Kinetics and Mechanical Regulation of Cardiac Muscle. In Interactive Phenomena in the Cardiac System. Sideman S., Beyar R., eds. Plenum Publishing Corp., NY, 1993; 59–77.
Landesberg A. Intracellular Mechanism in Control of Myocardial Mechanics and Energetics. In Analytical and Quantitative Cardiology: From Genetics to Function, S. Sideman and R. Beyar. eds. New York Plenum, 1997; 430: 75–87.
Allen D.G., Kentish J.C. The Cellular Basis of the Length Tension Regulation in Cardiac Muscle. J. Mol. Cellulal Biol., 1985; 17:821–40.
Eisenberg E., Hill T.L. Muscle Contraction and Free Energy Transduction in Biological System. Science. 1985; 227: 999–1006.
Fozzard H.A., Haber E., Jennings R.B., Katz A.M., Morgan H.E. The Heart and Cardiovascular System. Scientific Foundations. Second Edition. NY: Raven Press, 1991: 1281–95.
Hill A.V. The Heat of Shortening and Dynamic Constants of Shortening. Proc. Royal Soc. London (Biol) 1938; 126: 136–195.
Landesberg A., Livshitz L., ter Keurs HEDJ. The Effect of Sarcomere Shortening Velocity on Force Generation, Analysis of and Verification of Models for Crossbridge Dynamics. W. Herzog, ed. John Wiley and Sons, in press 2000.
Mulieri L.A., Luhr G., Tvefry J., Alpert N.R. Metal-Film Thermopiles for Use with Rabbit Right Ventricular Papillary Muscle. Am. J. Physiol. 1977; 233:C146–C156.
Cooper G.N. Load and Length Regulation of Cardiac Energetics. Annu. Rev. Physiol. 1990; 52: 505–522.
Alpert N.R., Mulieri L.A., Hasenfuss G., Holubarsch C. Optimization of Myocardial Function. In Myocardial Optimization and Efficiency: Evolutionary Aspects and Philosophy of Science Considerations. D. Burkhoff, J. Schaefer, K. Schaffne, D.T. Yue, eds. Springer-Verlag: NY, 1994; 29–41.
Alpert N.R., Mulieri L.A., Hasenfuss G. Myocardial Chemo-Mechanical Energy Transduction. In: The Heart and Cardiovascular System, 2nd Ed; HA Fozzard et al eds. Raven Press, NY, 1992; 111–128.
Alpert N.R., Mullieri L.A. Human Heart Failure: Determinants of Ventricular Dysfunction. In Analytical and Quantitative Cardiology, S. Sideman and R. Beyar, eds.Plenum Press, NY.1997; 97–108.
Hasenfuss G., Mullieri L.A., Blanchard E.M., Holubarsch C.H., Leavitt B.J., Ittleman F., Alpert N.R. Energetic of Isometric Force Development in Control and Volume Overload Human Myocardium: Comparison with Animal Species. Cir. Res. 1991; 68: 836–846.
Suga H., Goto Y., Kawaguchi O., Hata K., Takasago T., Sachi A., Taylor T.W. Ventricular Perspective of Efficiency. In Myocardial Optimization and Efficiency, Evolutionary Aspects and Philosphy of Science Consideration. D. Burkhoff, J. Schaefer, K. Schaffner, D.T. Yue (eds.) Basic Res. Cardiol., Springer-Verlag, NY. 1993; 88: 43–65.
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Sideman, S., Landesberg, A. (2002). Bioenergetics—Conversion of Biochemical to Mechanical Energy in the Cardiac Muscle. In: Afgan, N.H., da Graça Carvalho, M. (eds) New and Renewable Technologies for Sustainable Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0296-8_4
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DOI: https://doi.org/10.1007/978-1-4615-0296-8_4
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