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Neuronal and Vascular Plasticity pp 75–94Cite as

Restorative Potential of Angiogenesis after Ischemic Stroke

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Abstract

In the past decade, numerous attempts have been made to rescue neurons in the ischemic brain focusing on neuroprotective strategies. So far no effective clinical therapies have been developed based on neuroprotective mechanisms. It is increasingly recognized through recent clinical trials that preventing the activation of injurious events, that often become irreversible within a few hours of ischemia onset, is a difficult, if not impossible, task in the clinical setting. It appears rational that future investigations should consider alternative or additional approaches that repair the damaged brain and promote functional restoration during chronic phases of the disease which may be more clinically feasible. This article will provide a perspective on the potential of vascular plasticity in enhancing functional recovery after ischemic stroke. Selected findings based on animal studies from our and other laboratories are reviewed to support the relevance of vascular plasticity to functional recovery.

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Authors and Affiliations

  1. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA

    Ling Wei, Kejie Yin, Jin-Moo Lee, James Y. Chao, Shan Ping Yu & Chung Y. Hsu

  2. Academia Sinica and Taipei Medical University, Taipei, Taiwan

    Teng-Nan Lin & Chung Y. Hsu

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  1. Ling Wei
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  2. Kejie Yin
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  3. Jin-Moo Lee
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  4. James Y. Chao
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  5. Shan Ping Yu
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  6. Teng-Nan Lin
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  7. Chung Y. Hsu
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Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia Center for Molecular Medicine Institute for Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA

    Kenneth Maiese (Professor of Neurology and Anatomy & Cell Biology Director) (Professor of Neurology and Anatomy & Cell Biology Director)

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© 2003 Springer Science+Business Media New York

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Wei, L. et al. (2003). Restorative Potential of Angiogenesis after Ischemic Stroke. In: Maiese, K. (eds) Neuronal and Vascular Plasticity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0282-1_3

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  • DOI: https://doi.org/10.1007/978-1-4615-0282-1_3

  • Publisher Name: Springer, Boston, MA

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