Restorative Potential of Angiogenesis after Ischemic Stroke
In the past decade, numerous attempts have been made to rescue neurons in the ischemic brain focusing on neuroprotective strategies. So far no effective clinical therapies have been developed based on neuroprotective mechanisms. It is increasingly recognized through recent clinical trials that preventing the activation of injurious events, that often become irreversible within a few hours of ischemia onset, is a difficult, if not impossible, task in the clinical setting. It appears rational that future investigations should consider alternative or additional approaches that repair the damaged brain and promote functional restoration during chronic phases of the disease which may be more clinically feasible. This article will provide a perspective on the potential of vascular plasticity in enhancing functional recovery after ischemic stroke. Selected findings based on animal studies from our and other laboratories are reviewed to support the relevance of vascular plasticity to functional recovery.
KeywordsVascular Endothelial Growth Factor Middle Cerebral Artery Occlusion Basic Fibroblast Growth Factor Tumor Necrosis Factor Receptor Focal Cerebral Ischemia
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