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Pharmacology of Cyclic ADP-Ribose and NAADP

Synthesis and Properties of Analogs
  • Timothy F. Walseth
  • Hon Cheung Lee

Abstract

Multiple Ca2+ stores are generally present in cells. Principal among them are the mitochondria and the endoplasmic reticulum. It is generally accepted that inositol trisphosphate mobilizes Ca2+ stores in the endoplasmic reticulum [1]. Also present in the organelle is another Ca2+ release channel, the ryanodine receptor. The discovery of two other Ca2+ signaling molecules, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) [2–4] further highlights the complexity of Ca2+ mobilization as a fundamental signaling mechanism [1].

Keywords

Ryanodine Receptor Pancreatic Acinar Cell Nicotinamide Adenine Dinucleotide Phosphate Inositol Trisphosphate Nicotinic Acid Adenine Dinucleotide Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Timothy F. Walseth
    • 1
  • Hon Cheung Lee
    • 1
  1. 1.Department of PharmacologyUniversity of MinnesotaMinneapolisUSA

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