Oral L-arginine can reverse digital necrosis in Raynaud’s phenomenon
Raynaud’s phenomenon is characterized by transient reduction in blood supply through the small arteries in the hands and feet. Severe Raynaud’ s phenomenon can cause digital necrosis. It has been hypothesized that nitric oxide may have a role in Raynaud’s phenomenon. We report two cases in which oral L-arginine reversed digital necrosis in Raynaud’s phenomenon and two additional cases in which the symptoms of severe Raynaud’s phenomenon were improved with oral L-arginine. These reports suggest that a defect in nitric oxide synthesis or metabolism is present in Raynaud’s phenomenon. They also suggest a potential role for oral L-arginine therapy in Raynaud’s phenomenon, especially in Raynaud’s phenomenon with digital necrosis. (Mol Cell Biochem244:139-141, 2003)
Key wordL-arginine nitric oxide Raynaud’s phenomenon digital necrosis
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- 1.Lewis T: Experiments relating to the peripheral mechanisms involved in the spasmodic arrest of the circulation in the fingers, a variety of Raynaud’s disease. Heart 15: 7–99, 1929Google Scholar
- 3.Chen XL, Rembold CM: Nitroglycerin relaxes rat tail artery primarily by lowering Ca“ sensitivity and partially by repolarization. Am J Physiol Heart Circ Physiol 271: H962–H968, 1996Google Scholar
- 5.Murad F: Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system. Adv Pharmacol 26: 1933, 1994Google Scholar
- 9.Freedman RR, Girgis R, Mayes MD: Acute effect of nitric oxide on Raynaud’s phenomenon in scleroderma (letter). Lancet 28: 354–739, 1999Google Scholar