Oral L-arginine can reverse digital necrosis in Raynaud’s phenomenon

Abstract

Raynaud’s phenomenon is characterized by transient reduction in blood supply through the small arteries in the hands and feet. Severe Raynaud’ s phenomenon can cause digital necrosis. It has been hypothesized that nitric oxide may have a role in Raynaud’s phenomenon. We report two cases in which oral L-arginine reversed digital necrosis in Raynaud’s phenomenon and two additional cases in which the symptoms of severe Raynaud’s phenomenon were improved with oral L-arginine. These reports suggest that a defect in nitric oxide synthesis or metabolism is present in Raynaud’s phenomenon. They also suggest a potential role for oral L-arginine therapy in Raynaud’s phenomenon, especially in Raynaud’s phenomenon with digital necrosis. (Mol Cell Biochem244:139-141, 2003)