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Pituitary Adenylate Cyclase-Activating Polypeptide pp 361–399Cite as

The Biological Significance of PACAP and PACAP Receptors in Human Tumors: From Cell Lines to Cancers

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Part of the book series: Endocrine Updates ((ENDO,volume 20))

Abstract

PACAP (pituitary adenylate cyclase—activating polypeptide) belongs to a peptide family that includes VIP (vasoactive intestinal polypeptide) glucagon, secretin and other peptides such as the reptile exendins (Hezareth and Rawlings, 1996). PACAP and VIP are 70% homologous and share two common receptors called VPAC1 and VPAC2. PACAP possesses some very unique properties which are exerted through specific PACAP (PAC 1) receptors.

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Authors and Affiliations

  1. Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, USA

    V. Lelièvre, N. Pineau & J. A. Waschek

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  1. V. Lelièvre
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  2. N. Pineau
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  3. J. A. Waschek
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  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Lelièvre, V., Pineau, N., Waschek, J.A. (2003). The Biological Significance of PACAP and PACAP Receptors in Human Tumors: From Cell Lines to Cancers. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_17

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