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Function of PACAP in the Immune System

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Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

Abstract

Optimal host defense is the resultant of the regulatory interactions between the three systems implicated in the homeostasis of the organism: the nervous, endocrine and immune systems. These three systems constitute a complex network whose behavior, in the last twenty years, has been studied by a now well established area of research: the neuroimmunomodulation. This science has experienced an explosive growth not only in basic research, but also expanding to the point that prospective clinical research could be now a reality. A crucial factor for the functioning of this network was the demonstration that the cells of nervous, endocrine and immune systems synthesize and secrete similar substances bearing the same receptors for them, reducing traditional differences between neurotransmitters, hormones and immune mediators. The fact that neurons and endocrine cells possessed similar substances was soon established, and it was later when cells of the immune system were involved. In this sense, the first contributions performed in 1980 showed that macrophages and lymphocytes were able to produce ACTH and endorphins (Blalock and Smith, 1980). Moreover, some years later, two important facts demonstrated that lymphocytes were competent to produce peptidic hormones and neuropeptides: lymphocytes possess the biochemical machinery for a regulated secretory pathway as well as the necessary proteases, as furin and other convertases to process neuropeptides (Taplits et al, 1988;Decroly et al, 1996;1997).

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Authors and Affiliations

  1. Dept. Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid, 28040, Spain

    M. Delgado, J. Leceta & R. P. Gomariz

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  1. M. Delgado
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  2. J. Leceta
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  3. R. P. Gomariz
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Editors and Affiliations

  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Delgado, M., Leceta, J., Gomariz, R.P. (2003). Function of PACAP in the Immune System. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_14

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  • DOI: https://doi.org/10.1007/978-1-4615-0243-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4983-9

  • Online ISBN: 978-1-4615-0243-2

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