Sleep pp 665-672 | Cite as

Mood disorders and sleep

  • M. Kerkhofs


Disturbed sleep has long been recognised as one of the classic symptoms of mood disorder. Moreover, a high proportion of patients presenting sleep complaints are in fact suffering from an affective disorder [21]. Furthermore, sleep appears to sustain close links with mood disorders [54]. Indeed, if sleep is suppressed or reduced by total or partial deprivation, it proves to have antidepressant properties [26].


Depressed Patient Mood Disorder Panic Disorder NREM Sleep Polysomnographic Recording 
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  1. 1.
    ABER W., WEBB W.B. - Effects of a limited nap on night sleep in older subjects. Psychology and Aging, 1, 4, 300–302, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    ANSSEAU M., VON FRENCKELL R., FRANCK G., REYNOLDS III C.F., KUPFER D.J. - Sommeil et depression: vers une standardisation de 1’utilisation de la latence du sommeil paradoxal en tant que marqueur biologique de la depression majeure. Rev. E.E.G. Neurophysiol. Clin., 17, 411–424, 1987.Google Scholar
  3. 3.
    ARMITAGE R., CALHOUN J.S., RUSH A.J., ROFFWARG H.P. - Comparison of the delta EEG in the first and second non-REM periods in depressed adults and normal controls. Psychiatry Res., 41, 65–72, 1992.PubMedCrossRefGoogle Scholar
  4. 4.
    ARMITAGE R., HOFFMANN R., TRIVEDI M., RUSH A.J. - Slow-wave activity in NREM sleep: sex and age effects in depressed outpatients and healthy controls.Psychiatry Res., 95, 201–213, 2000.PubMedCrossRefGoogle Scholar
  5. 5.
    AVERY D., WILDSCHODTZ G., RAFAELSEN O. - REM latency and temperature in affective disorder before and after treatment. Biol. Psychiatry, 17, 4, 463–470, 1982.PubMedGoogle Scholar
  6. 6.
    BENCA R.M., OBERMEYER W.H., THISTED R.A., GILLIN J.CH. - Sleep and psychiatric disorders. A metaanalysis. Arch. Gen. Psychiatry, 49, 651–668, 1992.PubMedCrossRefGoogle Scholar
  7. 7.
    BERGER M., RIEMANN D., HOCHLI D., SPIEGEL R. - The cholinergic rapid eye movement sleep induction test with RS-86. Arch. Gen. Psychiatry, 46, 421–428, 1989.PubMedCrossRefGoogle Scholar
  8. 8.
    BORBELY A.A. - A two process model of sleep regulation. Hum. Neurobiol, 1, 195–204, 1982.PubMedGoogle Scholar
  9. 9.
    BORBELY A.A., WIRZ-JUSTICE A. - Sleep, sleep deprivation and depression. Hum. Neurobiol., 1, 205–210, 1982.PubMedGoogle Scholar
  10. 10.
    BORBELY A.A. - The S-Deficiency hypothesis of depression and the two-process model of sleep regulation. Pharmacopsychiat, 20, 23–29, 1987.CrossRefGoogle Scholar
  11. 11.
    CALDWELL D.F., DOMINO E.F. - Electroencephalographic and eye-movement pattern during sleep in chronic schizophrenic patients. Electroenceph. Clin. Neurophysiol. 22, 414–420, 1967.PubMedCrossRefGoogle Scholar
  12. 12.
    CHEN C.N. - Sleep, depression and antidepressants. Brit. J. Psychiat. 135, 385–402, 1979.PubMedCrossRefGoogle Scholar
  13. 13.
    COBLE P.A., FOSTER F.G., KUPFER D.J. - Electroencephalographic sleep diagnosis of primary depression. Arch. Gen. Psychiatry, 33, 1124–1127, 1976.PubMedCrossRefGoogle Scholar
  14. 14.
    DETRE T., HIMMELHOCH J., SWARTZBURG M., ANDERSON C.M., BYCK R., KUPFER D.J. -Hypersomnia and manic-depressive disease. Amer. J. Psychiat., 128, 10, 1303–1305, 1972.PubMedGoogle Scholar
  15. 15.
    DEW M.A., REYNOLDS Ch.F., BUYSSE D.J., HOUCK P.R., HOCH C.C., MONK T.H., KUPFER D.J. -Electroencephalographic sleep profile during depression. Arch. Gen. Psychiatry, 53, 148–156, 1996.PubMedCrossRefGoogle Scholar
  16. 16.
    DUBE S., JONES D.A., BELL J., DAVIES A., ROSS E., SITARAM N. - Interface of panic and depression: Clinical and sleep EEG correlates. Psychiatry Res., 19, 119–133, 1986.PubMedCrossRefGoogle Scholar
  17. 17.
    ELSENGA S., VAN DEN HOOFDAKKER R.H. - Clinical effects of several sleep-wake manipulations on endogenous depression. Sleep Res. 12, 326, 1983.Google Scholar
  18. 18.
    FEINBERG I., BRAUN M., KORESKO R.L., GOTTLIEB F. - Stage 4 sleep in schizophrenia. Arch. Gen. Psychiat., 21, 262–266, 1969.PubMedCrossRefGoogle Scholar
  19. 19.
    FEINBERG M., GILLIN J.C., CARROLL B.J., GREDEN J.F., ZIS A.P. - EEG studies of sleep in the diagnosis of depression. Biol. Psychiatry, 17, 305–316, 1982.PubMedGoogle Scholar
  20. 20.
    FEINBERG I., MARCH J.D., FLOYD T.C., JIMISON R., BOSSOM-DEMITRACK L., KATZ P.H. -Homeostatic changes during post-nap sleep maintain baseline levels of delta EEG. Electroenceph. Clin. Neurophysiol. 61, 134–137, 1985.PubMedCrossRefGoogle Scholar
  21. 21.
    FORD D.E., KAMEROW D.B. - Epidemiologic study of sleep disturbances and psychiatric disorders: an opportunity for prevention? JAMA, 262, 1479–1484, 1989.PubMedCrossRefGoogle Scholar
  22. 22.
    GAILLARD J.M. - Sommeil et psychotropes. J. Pharmacol., 15, 4, 389–399, 1984.PubMedGoogle Scholar
  23. 23.
    GANGULI R., REYNOLDS III Ch.F., KUPFER D.J. - Electroencephalographic sleep in young never-medicated schizophrenics. Arch. Gen. Psychiatry, 44, 36–44, 1987.PubMedCrossRefGoogle Scholar
  24. 24.
    GILES D.E., JARRETT R.B., ROFFWARG H.P., RUSH A.J. - Reduced rapid eye movement latency: a predictor for recurrence in depression. Neuropsychopharmacology, 1, 1,33–39, 1987.PubMedCrossRefGoogle Scholar
  25. 25.
    GILES D.E., ROFFWARG H.P., SCHLESSER M.A., RUSH A.J. - Which endogenous depressive symptoms relate to REM latency? Biol. Psychiatry, 21, 473–482, 1986.PubMedCrossRefGoogle Scholar
  26. 26.
    GILLIN J.Ch. - The sleep therapies of depression. Prog. Neuro-Psychopharmacol. Bol. Psychiat., 7, 351–364, 1983.CrossRefGoogle Scholar
  27. 27.
    GILLIN J. Ch., DUNCAN W.C., MURPHY D.L., POST R.M., WEHR T.A., GOODWIN F.K., WYATT R.J., BUNNEY Jr.W.E. - Age related changes in sleep in depressed and normal subjects. Psychiatry Res. 4, 73–78, 1981.PubMedCrossRefGoogle Scholar
  28. 28.
    GILLIN J.Ch., DUNCAN W.C., PETTITGREW K.D., FRANKEL B.L., SNYDER F. - Successful separation of depressed, normal and insomniac subjects by EEG sleep data. Arch. Gen. Psychiatry, 36, 85–90, 1979.PubMedCrossRefGoogle Scholar
  29. 29.
    GILLIN J.Ch., SITARAM N., DUNCAN W.C. - Muscarinic supersensitivity: A possible model for the sleep disturbance of primary depression? Psychiatry Res., 1, 17–22, 1978.CrossRefGoogle Scholar
  30. 30.
    GILLIN J.Ch., SMITH T.L., IRWIN M., KRIPKE D.F., SCHUCKIT M.- EEG sleep studies in « pure » primary alcoholism during subacute withdrawal: relationships to normal controls, age and other clinical variables. Biol. Psychiatry, 27, 477–488, 1990.PubMedCrossRefGoogle Scholar
  31. 31.
    GILLIN J.Ch.WYATT R.J., FRAM D., SNYDER F. - The relationship between changes in REM sleep and clinical improvement in depressed patients treated with amitriptyline. Psychoparmacology, 59, 267–272, 1978.CrossRefGoogle Scholar
  32. 32.
    HAWKINS D.R., TAUB J.M., VAN DE CASTLE R.L. - Extended sleep (hypersomnia) in young depressed patients. Am. J. Psychiatry, 142, 905–910, 1985.PubMedGoogle Scholar
  33. 33.
    HIATT J.F., FLOYD T.C., KATZ P.H., FEINBERG I. - Further evidence of abnormal non-rapid-eye-movement sleep in Schizophrenia. Arch. Gen. Psychiatry, 42, 797–802, 1985.PubMedCrossRefGoogle Scholar
  34. 34.
    HOCHLI D., RIEMANN D., ZULLEY J., BERGER M. - Initial REM suppression by clomipramine: a prognostic tool for treatment response in patients with a major depressive disorder. Biol. Psychiatry, 21, 1217–1220, 1986.PubMedCrossRefGoogle Scholar
  35. 35.
    INSEL Th.R., GILLIN J.Ch., MOORE A., MENDELSON W.B., LOEWENSTEIN R.J., MURPHY D.L. - The sleep of patients with obsessive-compulsive disorder. Arch. Gen. Psychiatry, 39, 1372–1377, 1982.PubMedCrossRefGoogle Scholar
  36. 36.
    JANOWSKY D.L., EL-YOUSEF M.K., DAVIS J.M. - A cholinergic-adrenergic hypothesis of mania and depression. The Lancet, ii, 632–635,1972.CrossRefGoogle Scholar
  37. 37.
    KARACAN I., FINLEY W., WILLIAMS R.L., HURSCH C.J. - Changes in stage 1 - REM and stage 4 sleep during naps. Biol. Psychiatry, 2, 391–399, 1970.PubMedGoogle Scholar
  38. 38.
    KARACAN I., WILLIAMS R.L., FINLEY W.W., HURSCH C.J. - The effects of naps on nocturnal sleep: Influence on the need for stage-1 REM and stage 4 sleep. Biol. Psychiatry, 2, 391–399, 1970.PubMedGoogle Scholar
  39. 39.
    KEMPENAERS C., KERKHOFS M., LINKOWSKI P., MENDLEWICZ J. - Sleep EEG variables in young schizophrenic and depressive patients. Biol. Psychiatry, 24, 828–833, 1988.CrossRefGoogle Scholar
  40. 40.
    KERKHOFS M., KEMPENAERS C., LINKOWSKI P., DE MAERTELAER V., MENDLEWICZ J. -Multivariate study of sleep EEG in depression. Acta Psychiatr. Scand., 77, 463–468, 1988.PubMedCrossRefGoogle Scholar
  41. 41.
    KERKHOFS M., LINKOWSKI P., LUCAS F., MENDLEWICZ J. - 24-hour patterns of sleep in depression. Sleep, 14,6, 501–506, 1991.PubMedGoogle Scholar
  42. 42.
    KERKHOFS M., MENDLEWICZ J. - The effects of antidepressant treatment on sleep disturbances in depression. Eur. Psychiatry, 10, 391–396, 1995.PubMedCrossRefGoogle Scholar
  43. 43.
    KRIEG J.C., LAUER C.J., SCHREIBER W., MODELL S., HOLSBOER F. - Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the « Munich vulnerability study ». J. of Affective Dis., 62, 33–37, 2001.CrossRefGoogle Scholar
  44. 44.
    KUPFER D.J. - REM latency: A psychobiologic marker of primary depressive disease. Biol. Psychiatry, 11, 159–174, 1976.PubMedGoogle Scholar
  45. 45.
    KUPFER D.J., FOSTER F.G. - EEG sleep and depression. Sleep disorders diagnosis and treatment. R.L. Williams, I. Karacan (eds), John Wiley, New York, 1978.Google Scholar
  46. 46.
    KUPFER D.J., FOSTER F.G., COBLE P., McPARTLAND R.J., ULRICH R.F. - The application of EEG sleep for the differential diagnosis of affective disorders. Am. J.Psychiatry, 135, 69–74, 1978.PubMedGoogle Scholar
  47. 47.
    KUPFER D.J., REYNOLDS III C.F., ULRICH R.F., SHAW D.J., COBLE P.A. - EEG sleep, depression and aging. Neurobiol. Aging., 3, 351–360, 1982.PubMedCrossRefGoogle Scholar
  48. 48.
    KUPFER D.J., SPIKER D.G., COBLE P.A., NEIL J.F., ULRICH R.F., SHAW D.H. - Depression, EEG sleep and clinical response. Compr. Psychiatry, 21,3, 212–220, 1980.PubMedCrossRefGoogle Scholar
  49. 49.
    KUPFER D.J., SPIKER D.G., COBLE P.A., NEIL J.F., ULRICH R.F., SHAW D.H. - Sleep and treatment prediction in endogenous depression. Am. J. Psychiatry, 138, 429–434, 1981.PubMedCrossRefGoogle Scholar
  50. 50.
    LAUER J. Ch., KRIEG J.Ch., GARCIA-BORREGUERO D., OZDAGLAR A., HOLSBOER F. - Panic disorder and major depression: a comparative electroencephalographic sleep study. Psychiatry Res., 44, 41–54, 1992.PubMedCrossRefGoogle Scholar
  51. 51.
    LAUER J.Ch., SCHREIBER W., HOLDSBOER F., KRIEG J.Ch. - In quest of identifying vulnerability markers for psychiatric disorders by all-night polysomnography. Arch. Gen. Psychiatry, 52, 145–153, 1995.PubMedCrossRefGoogle Scholar
  52. 52.
    LINKOWSKI P., MENDELWICZ J., KERKHOFS M., LECLERCQ R., GOLDSTEIN J., BRASSEUR M., COPINSCHI G., VAN CAUTER E. - 24-hour profiles of adrenocorticotropin, cortisol and growth hormone in major depressive illness: effect of antidepressant treatment. J. Clin. Endocrinol. Metab., 65, 141–151, 1987.PubMedCrossRefGoogle Scholar
  53. 53.
    LINKOWSKI P., MENDLEWICZ J., LECLERCQ R., BRASSEUR M., HUBAIN P., GOLDSTEIN J., COPINSCHI G., VAN CAUTER E. - The 24 hour profile of adrenocorticotropin and cortisol in major depressive illness. J. Clin. Endocrinol. Metab., 61, 429–438, 1987.CrossRefGoogle Scholar
  54. 54.
    LUSTBERG L., REYNOLDS Ch.F.III - Depression and insomnia: questions of cause and effect. Sleep Medicine Rev., 4, 253–262, 2000.CrossRefGoogle Scholar
  55. 55.
    McCARLEY R.W. - Sleep and depression: common neurobiological control mechanisms. Am. J. Psychiatry, 139, 565–570, 1982.PubMedGoogle Scholar
  56. 56.
    McCARLEY R .W., HOBSON J.A. - Sleep-cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science, 189, 55–60, 1975.PubMedCrossRefGoogle Scholar
  57. 57.
    McCARLEY R.W., MASSAQUOI S.G. - A limit cycle mathematical model of the REM sleep oscillator system. Amer. J. Physiol., 251, R1011–R1029, 1986.PubMedGoogle Scholar
  58. 58.
    MENDELWICZ J., KEMPENAERS C., DE MAERTELAER V. - Sleep EEG and amitriptyline treatment in depressed inpatients. Biological Psychiatry, 30, 691–702, 1991.CrossRefGoogle Scholar
  59. 59.
    MENDELWICZ J., KERKHOFS M. - Sleep EEG in depressive illness: A world health organization collaborative study. Brit. J. Psychiatry, 159, 505–509, 1991.CrossRefGoogle Scholar
  60. 60.
    OBERNDORFER S., SALETU-ZYHLARZ G., SALETU B. - Effects of selective serotonin inhibitors on objective and subjective sleep quality. Neuropsychobiology, 42, 69–81, 2001.CrossRefGoogle Scholar
  61. 61.
    PAPADIMITRIOU G.N., KERKHOFS M., KEMPENAERS C., MENDELWICZ J. - EEG sleep studies in patients with generalized anxiety disorder. Psychiatry Res., 26, 183–190, 1988.PubMedCrossRefGoogle Scholar
  62. 62.
    REYNOLDS III Ch.F., KUPFER D.J. - Sleep research in affective illness: state of the art circa 1987. Sleep, 10, 3, 199–215, 1987.PubMedGoogle Scholar
  63. 63.
    REYNOLDS III Ch.F., KUPFER D.J., TASKA L.S., HOCH C.C., SPIKER D.G., SEWICH D.E., ZIMMER B., MARIN R.S., NELSON J.P., MARTIN D., MORYCZ R. - EEG sleep in elderly depressed, demented and healthy subjects. Biol. Psychiatry, 20, 431–442, 1985.PubMedCrossRefGoogle Scholar
  64. 64.
    REYNOLDS III Ch.F., SHAW D.H., NEWTON T.F., COBLE P.A., KUPFER D.J. - EEG sleep in outpatients with generalized anxiety: a preliminary comparison with depressed outpatients. Psychiatry Res. 8, 81–89, 1983.PubMedCrossRefGoogle Scholar
  65. 65.
    RUSH A.J., GILES D.E., JARRETT R.B., PELDMAN-KOFFLER F., DEBUS J.R., WEISSENBURGER J., ORSULAK P.J., ROFFWARG H.P. - Reduced REM latency predicts response to tricyclic medication in depressed outpatients. Biol. Psychiatry, 26, 61–72, 1989.PubMedCrossRefGoogle Scholar
  66. 66.
    SCHULZ H., LUND R. - On the origin of early REM episodes in the sleep of depressed patients: A comparison of three hypothesis.Psychiatry Res. 16, 65–77, 1985.PubMedCrossRefGoogle Scholar
  67. 67.
    SHIMIZU A., HIYAMA H., YAGASAKI A., TAKAHASHI H., FUYIKI A., YOSHIDA I. - Sleep of depressed patients with hypersomnia: A 24-h polygraphic study. Waking and Sleeping, 3, 335–339, 1979.PubMedGoogle Scholar
  68. 68.
    SITARAM N., NURNBERGER J.L., GERSHON E.S., GILLIN J.C. - Cholinergic regulation of mood and REM sleep: a potential model and marker for vulnerability to depression. Am. J. Psychiatry, 139, 571–576, 1982.PubMedGoogle Scholar
  69. 69.
    THASE M.E., HIMMELHOCH J.M., MALLINGER A.G., JARRETT D.B., KUPFER D.J. - Sleep EEG and DST findings in anergic bipolar depression. Am. J. Psychiatry, 146, 3, 329–333, 1986.Google Scholar
  70. 70.
    THASE M.E., KUPFER D.J., SPIKER D.G. - Electroencephalographic sleep in secondary depression: A revisit. Biol. Psychiatry, 19, 6, 805–810, 1984.PubMedGoogle Scholar
  71. 71.
    THASE M.E., KUPFER D.J., ULRICH R.F. - Electroencephalographic sleep in psychotic depression. A valid subtype? Arch. Gen. Psychiatry, 43, 886–893, 1986.PubMedCrossRefGoogle Scholar
  72. 72.
    THASE M.E., SIMONS A.D., REYNOLDS Ch.F. III - Abnormal electroencephalographic sleep profile in major depression. Arch. Gen. Psychiatry, 53, 99–108, 1996.PubMedCrossRefGoogle Scholar
  73. 73.
    UHDE Th.W., ROY-BYRNE P., GILLIN J. Ch., MENDELSON W.B., BOULENGER J.Ph., VITTONE B.J., POST R.M. - The sleep of patients with panic disorder: A preliminary report. Psychiatry Res. 12, 251–259, 1984.PubMedCrossRefGoogle Scholar
  74. 74.
    ULRICH R.F., SHAW D.H., KUPFER D.J. - Effects of aging on EEG sleep in depression. Sleep, 3, 31–40, 1980.PubMedGoogle Scholar
  75. 75.
    WEHR T.A., WIRZ-JUSTICE A., GOODWIN F.K., DUNCAN W., GILLIN J.C. - Phase advance of the sleep-wake cycle as an antidepressant. Science, 206, 710–713, 1979.PubMedCrossRefGoogle Scholar
  76. 76.
    ZARCONE V.P., BENSON K.L., BERGER PA. - Abnormal rapid eye movement latencies in schizophrenia. Arch. Gen. Psychiatry, 44, 45–48, 1987.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2003

Authors and Affiliations

  • M. Kerkhofs
    • 1
  1. 1.Laboratoire de Sommeil, Centre Hospitalo-Universitaire de CharleroiHôpital A. VésaleMontigny-le-TilleulBelgique

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