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Nocturnal hypoxemia in chronic obstructive pulmonary disease

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Sleep

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Abstract

The notion that sleep can accentuate hypoxemia in patients with chronic obstructive pulmonary disease (COPD) has been understood for almost 40 years [44]. The earliest nocturnal polygraphic studies of patients go back to 1975-1976 [32, 33] and include intermittent blood gas tension measurements during sleep. But it was only with the advent of reliable transcutanous oximeters in 1976, that the respiratory “events” occurring during sleep could be clearly defined. After the landmark study of Flick and Block in 1977, [27] several studies [5, 7, 15, 17, 35, 42, 47] went on to show that COPD patients experienced a worsening of hypoxemia, particularly during REM sleep. The initial studies focused almost entirely on patients with severe cases who were clearly hypoxemic during the daytime. It was only later [25, 34, 45] that data appeared for nocturnal hypoxemia in COPD patients with little or no hypoxemia during the day (PaO2 > 60 mmHg).

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Authors and Affiliations

  1. Service de Pneumologie, Hôpital de Hautepierre, Strasbourg, France

    E. Weitzenblum, A. Chaouat, C. Charpentier & R. Kessler

  2. Service des Explorations Fonctionnelles du Système Nerveux et de Pathologie du Sommeil, Strasbourg, France

    J. Kreiger

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  1. E. Weitzenblum
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  2. A. Chaouat
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  4. R. Kessler
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  1. Hôpital Gui de Chauliac, Montpellier, France

    Michel Billiard

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Weitzenblum, E., Chaouat, A., Charpentier, C., Kessler, R., Kreiger, J. (2003). Nocturnal hypoxemia in chronic obstructive pulmonary disease. In: Billiard, M. (eds) Sleep. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0217-3_44

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  • DOI: https://doi.org/10.1007/978-1-4615-0217-3_44

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