Skip to main content
SpringerLink
Log in

Recurrent hypersomnias

  • Chapter
Sleep

  • 696 Accesses

Abstract

These refer to a group of relatively rare disorders characterised by episodes of more or less continuous sleep, with an average duration of one week, recurring at highly variable intervals of between one and several months or even several years. The classic picture is that of the Kleine-Levin syndrome in which sleep episodes are associated with other symptoms, eating or sexual disorders and psychological disturbance. The origin is still unknown. In addition to the Kleine-Levin syndrome, recurrent hypersomnias symptomatic of organic or psychiatric disorders may be encountered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. ANFIMOFF, J. - A. Quoted by Kaplinsky and Schulman, 1935

    Google Scholar 

  2. BARONTNI, F. ZAPPOLI R. - A case of Kleine-Levin Syndrome. Clinical and polygraphic study. Proceedings of the Twentieth European Meeting on Electroencephalography. Aulo Gaggi, Bologna, 239–245, 1967.

    Google Scholar 

  3. BILLIARD M., - Recurring hypersomnias. In: Sleep 1978, L. Popoviciu, B. Asgian, G. Badiu (eds), Karger, Basel, 233–239, 1980.

    Google Scholar 

  4. BILLIARD M., CADILHAC J. - Les hypersomnies récurrentes. Rev. Neurol. (Paris) 144, 249–258, 1980.

    Google Scholar 

  5. BILLIARD M., GUILLEMINAULT C., DEMENT W.C. - A menstruation-linked periodic hypersomnia. Neurology, 25, 436–443, 1975.

    Article  PubMed  CAS  Google Scholar 

  6. BONKALO A. - Hypersomnia: a discussion of psychiatric implication based on three cases. Br. J. Psychiat. 114, 69–75 1968.

    Article  CAS  Google Scholar 

  7. BUCKING P.H., PALMER W.R. - New contribution to the clinical aspects and pathophysiology of the Kleine-Levin syndrome. Munch. Med. Wochenschr., 120, 1571–1572, 1978.

    CAS  Google Scholar 

  8. BURTON S.A. - Recovery from sleep attacks in Kleine-Levin syndrome may involve a process of gradual phase advance. Sleep Res., 18, 209, 1989.

    Google Scholar 

  9. CARPENTER S., YASSA R., OCHS R. - A pathological basis for Kleine-Levin syndrome. Arch. Neurol. 39, 25–28, 1982.

    CAS  Google Scholar 

  10. CHESSON A.L., LEVINE S.N. - Neurendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence. Sleep, 14, 226–232, 1991.

    PubMed  Google Scholar 

  11. CRJTCHLEY M. - Periodic hypersomnia and megaphagia in adolescent males. Brain, 85, 627–656, 1962.

    Google Scholar 

  12. CRJTCHLEY M., HOFFMAN H.L. - The syndrome of periodic somnolence and morbid hunger (Kleine-Levin syndrome). BM.J. 1, 137–139, 1942.

    Article  Google Scholar 

  13. DAUVILLIERS Y., MAYER G., LECENDREUX M., NEIDHART E., CHAPPUIS R., BILLIARD M., TAFTI M. - Possible association of polymorphisms in the HLA and monoaminergic systems in Kleine-Levin syndrome. Sleep 23, Abstract Supplement 2, 2000. A 63–64.

    Google Scholar 

  14. DUFFY J.P., DAVISON K. - A female case of Kleine-Levin syndrome. Brit. J. Psychiat., 114, 77–84, 1968.

    Article  CAS  Google Scholar 

  15. FENZI F., SIMONATI A., CROSATO F., GHERSINI L;, RIZZUTO N. - Clinical features of Kleine-Levin syndrome with lithium. Can. J. Psychiatry. 28, 491–493, 1983.

    Google Scholar 

  16. FERNANDEZ J.M., LARA I., GILA L., O’NEILL OF TYRONE A., TOVAR J., GIMENO A. - Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome. Acta. Neurol. Scand. 82, 361–363, 1990.

    Article  PubMed  CAS  Google Scholar 

  17. GABRIEL P. - L·espinéalomes (étude anatomo-clinique) 1 vol. 252p., Maloine, Paris, 1935.

    Google Scholar 

  18. GADOTH N., DICKERMAN Z., BECHAR M., LARON Z., LAVIE P. - Episodic hormone secretion during sleep in Kleine-Levin syndrome: evidence for hypothalamus dysfunction. Brain Dev. 9, 309–315, 1987.

    Article  PubMed  CAS  Google Scholar 

  19. GILLIGAN B.S. - Periodic megaphagia and hypersomnia. An example of the Kleine-Levin syndrome in an adolescent girl. Proc. Austr. Assoc. Neurol., 9, 67–72, 1973.

    CAS  Google Scholar 

  20. GODENNE G.D. - Report of a case of recurring hysterical pseudostupor. J. Nerv. Mental Dis., 141, 670–677, 1966.

    Article  Google Scholar 

  21. GOLDBERG M.A. - The treatment of Kleine-Levin syndrome with lithium. Can. J. Psychiatry. 28, 491–493, 1983.

    PubMed  CAS  Google Scholar 

  22. GORDON A. - Encéphalite léthargique des centres végétatifs. Syndrome de somnolence périodique avec polyphagie et polydypsie.Rev. Neurol. (Paris) 71, 411–416, 1939.

    Google Scholar 

  23. GRAN D., BEGEMANN H. - Neue Beobachtungen bei einem Fall von Kleine-Levin -Syndrom. Munch. Med. Wochenschr., 115, 1098–1102, 1973.

    PubMed  CAS  Google Scholar 

  24. GROSSIORD A. - Le kyste colloïde du 3ème ventricule. Thesis, Paris, 1941.

    Google Scholar 

  25. GUILLAIN G., BERTRAND I., PERISSON. - Etude anatomo-clinique d’une tumeur du 3ème ventricule. Rev. Neurol. (Paris), 41, 467–473, 1925.

    Google Scholar 

  26. HART E.J. - Kleine-Levin syndrome: normal CSF monoamines and response to lithium therapy. Neurology, 35, 1395–1396, 1985.

    Article  PubMed  CAS  Google Scholar 

  27. HEGARTY A., MERRIAM A.E. - Autonomic events in Kleine-Levin syndrome. Am. J. Psychiatry, 147, 951–952, 1990.

    PubMed  CAS  Google Scholar 

  28. HISHIKAWA Y., IIJIMA S., TASHIRO T., SUGITA Y., TESHITA Y., MATSUO R., KANEDA H. -Polysomnographic findings and growth hormone secretion in patients with periodic hypersomnia. In: Sleep 90, W. P. Koella(ed.), Karger, Basel, 128–133, 1981.

    Google Scholar 

  29. JEFFRIES J.J., LEFEBVRE A. - Depression and mania associated with Kleine-Levin-Critchley syndrome. Can Psychiatr. Assoc. J. 18, 439–444, 1973.

    PubMed  CAS  Google Scholar 

  30. KANEDA H., SUGITA Y., MASAOKA S., IIJIMA S., TANAKA K., WAKAMATSU H., HISHIKAWA Y. -Red blood cell concentration and growth hormone release in periodic hypersomnia. Waking and Sleeping. I, 369–374, 1977.

    Google Scholar 

  31. KAPLINSKY M.S., SCHULMANN E.D. - Uber die periodische Schlafsucht (I; Mitteilung), Acta. Med. Scand., 85, 107–128, 1935.

    Article  Google Scholar 

  32. KLEINE W. - Periodische Schlafsucht. Mschr. Psychiat. Neurol., 57, 285–320, 1925.

    Article  Google Scholar 

  33. KOERBER R.K., TORKELSON R., HAVEN G., DONALDSON J., COHEN S.M., CASE M., Increased cerebrospinal fluid 5-hydroxytryptmine and 5-hydroxyindoleacetic acid in Kleine-Levin syndrome. Neurology, 34, 1597–1600, 1984.

    Article  PubMed  CAS  Google Scholar 

  34. LAVIE P., GADOTH N., GORDON C.R., GOLDHAMMER G., BECHAR M. - Sleep patterns in Kleine-Levin syndrome. Electroenceph. Clin. Neurophysiol., 47, 369–371, 1979.

    Article  PubMed  CAS  Google Scholar 

  35. LAVIE P., KLEIN E., GADOTH N., BENTAL E., ZOMER J., BECHAR M., WASJBORT J. - Further observations on sleep abnormalities in Kleine-Levin syndrome: abnormal breathing pattern during sleep. Electroenceph. Clin. Neurophysiol., 52, 98–101, 1981.

    Article  PubMed  CAS  Google Scholar 

  36. LEVIN M. - Narcolepsy (Gelineau’s syndrome) and other varieties of morbid somnolence. Arch. Neurol. Psychiatr., (Chicago) 22, 1172–1200, 1929.

    Article  Google Scholar 

  37. LEVIN M. - Periodic somnolence and morbid hunger: a new syndrome. Brain, 59, 494–504, 1936.

    Article  Google Scholar 

  38. LEWIS N.D.C. - The psychoanalytic approach to the problem of children under twelve years of age. Psychoanalytic Review, 13, 424–443, 1926.

    Google Scholar 

  39. LHERMITTE J., DUBOIS E. - Crises d’hypersomnie prolongée rythmée par les règies chez une jeune fille. Rev. Neurol. (Paris) 73, 608–609, 1941.

    Google Scholar 

  40. LHERMITTE J., HECAEN H., BINEAU L., Un nouveau cas d’hypersomnie prolongée rythmée par les règies. Rev. Neurol., (Paris) 75, 299, 1943.

    Google Scholar 

  41. LIN L., FARACO J., LI R., KADOTANI H., ROGERS W., LIN X., QUI X., DE JONG P.J., NISHINO S., MIGNOT E. - The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell, 98, 365–376, 1999.

    Article  PubMed  CAS  Google Scholar 

  42. LINDON L.C.A. - Cystic tumours of the third ventricle. Med. J. Aust., 2, 122–124, 1938.

    Google Scholar 

  43. LIVREA P., PUCA F.M., BARNABA A., DIREDA L. - Abnormal central monoamine metabolism in humans with “true hypersomnia” and “sub-wakefulness”,Eur. Neurol., 15, 71–76, 1977.

    Article  PubMed  CAS  Google Scholar 

  44. MAYER G., LEONHARD E., KRIEG J., MEIER-EWERT K. - Endocrinological and polysomnographic findings in Kleine-Levin syndrome. No evidence for hypothalamic and circadian dysfunction. Sleep, 21, 278–284, 1998.

    PubMed  CAS  Google Scholar 

  45. MERRIAM A.E. - Kleine-Levin syndrome following acute viral encephalitis. Biol. Psychiatry, 21, 1301–1304, 1986.

    Article  PubMed  CAS  Google Scholar 

  46. MUKADDES N.H., KORA M.E., BILGE S. - Carbamezepine for Kleine-Levin syndrome. J. Am. Acad. Child. Adolesc. Psychiatry, 38, 791–792, 1999.

    Article  PubMed  CAS  Google Scholar 

  47. PAPY J.J., CONTE-DEVOIX B., SORMANI J., PORTO R., GUILLAUME V. - Syndrome d’hypersomnie périodique avec mégaphagie chez une jeune femme, rythmé par le cycle menstruel. Rev. E.E.G. Neurophysiol. Clin. 12, 54–61, 1982.

    CAS  Google Scholar 

  48. PEYRON C., TIGHE D., VAN DEN POL A., DE LECEA L., HELLER H., SUTCLIFFE J., KILDUFF T. -Neurons containing hypocretin (orexin) project to multiple neuronal systems.J. Neurosci. 18, 9996–10015, 1998.

    PubMed  CAS  Google Scholar 

  49. POHL O., HAIRS G. - Hypomanic psychosis alternating with periodical hypersomnia. Psychiat. Clin., 1, 120–124, 1968.

    CAS  Google Scholar 

  50. POPOVICIU L., CORFARIU O. - Etude clinique et polygraphique au cours du nycthémère d’un cas de syndrome Kleine-Levin-Critchley. Rev. Roum. Neurol., 9, 221–228, 1972.

    PubMed  CAS  Google Scholar 

  51. REYNOLDS C.F., BLACK R.S., COBLE P.A., HOLZER B., KUPFER D.J. - Similarities in EEG sleep findings for Kleine-Levin syndrome and unipolar depression. Am. J. Psychiatry, 137, 116–118, 1980.

    PubMed  Google Scholar 

  52. REYNOLDS C.F., KUPFER D.J., CHRISTIANSEN C.L., AUCHENBACH R.C., BRENNER R.P., SEWITCH D.E., TASKA L.S., COBLE P.A. - Multiple sleep latency test findings in Kleine-Levin syndrome. J. Nerv.Ment. Dis., 172,41–44, 1984.

    Article  PubMed  CAS  Google Scholar 

  53. REYNOLDS C.F., SHUBIN R.S., COBLE P.A., KUPFER D.J. - Diagnosis classification of sleep disorders: implications for psychiatric practice. J. Clin. Psychiatry, 41, 296–299, 1981.

    Google Scholar 

  54. ROBINSON J.T., MCQUILLAN J. - Schizophrenic reaction associated with the Kleine-Levin syndrome. Medicine, Baltimore, 96, 377–381, 1951.

    CAS  Google Scholar 

  55. ROTH B. - Functional hypersomnia. In: Narcolepsy, C. Guilleminault, W.C. Dement, P. Passouant (eds.), Spectrum Publ., New York, 333–349, 1976.

    Google Scholar 

  56. ROTH B., NEVSIMALOVA S. - The clinical picture of periodic hypersomnia: a study of 38 personally observed cases. In: Sleep 1980, W.P. Koella (ed.), Karger, Basel, 120–124, 1981.

    Google Scholar 

  57. ROTH B., SMOLIK P., SOUCEK K. - Kleine-Levin syndrome. Lithoprophylaxis. Ceskolovenska Psychiatrie, 76, 156–162, 1980.

    CAS  Google Scholar 

  58. RUSSEL J., GRUNSTEIN R. - Kleine-Levin syndrome: a case report. Aust. N.Z.J. Psychiatry, 26, 119–123, 1992.

    Article  Google Scholar 

  59. SACHS C, PERSSON H.E., HAGENFELDT K. - Menstuation-related periodic hypersomnia: a case study with successful treatment. Neurology, 32, 1376–1379, 1982.

    Article  PubMed  CAS  Google Scholar 

  60. SAGRIPANTI P. - Sull’associazione di ipersomnia e bulimia (syndrome di Kleine-Levin). Il Cervello, 194, 194–205, 1952.

    Google Scholar 

  61. SALTERS M.S., WHITE P.D. - A variant of Kleine-Levin precipitated by both Epstein-Barr and Varicella-Zoster virus infections. Biol. Psychiatry, 33, 388–390, 1993.

    Article  Google Scholar 

  62. SAVET J.F., ROBERT H., ANGELI C. - Un cas de syndrome de Kleine-Levin stabilisé depuis plus d’un an sous carbamazépine. Presse Med. 15, 281, 1986.

    Google Scholar 

  63. SEMIONOWA-TIAN-SHANSKAYA V.V. - Periodic pathological sleep. Zh. Nevropat. Psikhiat., 66, 3–9, 1966.

    Google Scholar 

  64. SMIRNE S., CASTELOTTI V., PASSERINI D. - EEG study in a case of Kleine-Levin syndrome. Revista di Neurologia, 40, 357–365, 1970.

    CAS  Google Scholar 

  65. TAKAHASHI Y. - Clinical studies of periodic somnolence. Analysis of 28 personal cases. Psychiat. Neurol. Jap., 67, 853–889, 1965.

    CAS  Google Scholar 

  66. TAKRANI L.B., CRONIN D. - Kleine-Levin syndrome in a female patient. Can. Psychiatry Assoc. J., 21,315–318,1976.

    CAS  Google Scholar 

  67. THACORE V.R., AHMED M., OSWALDI I. - The EEG in a case of periodic hypersomnia. EEG Clin. Neurophysiol., 27, 605–606, 1969.

    Article  CAS  Google Scholar 

  68. THOMPSON C., OBRECHT R., FRANEY C., ARENDT J., CHECKLEY S.A. - Neuroendocrine rhythms in a patient with the Kleine-Levin syndrome. Br. J. Psychiatry, 147, 440–443, 1985.

    Article  PubMed  CAS  Google Scholar 

  69. DE VILLARD R., DELIRY J., MOURET J., MAILLET J., CHARRAT A. - Le syndrome de Kleine-Levin: à propos de 4 cas. Lyon Médical, 244, 389–394, 1980.

    Google Scholar 

  70. VOLLMER R., TOIFL K., KOTHBAUER P., RIEDERER P. - EEG und biochemische Befunde beim Kleine-Levin - Syndrom. Nervenarzt., 52, 211–218, 1981.

    PubMed  CAS  Google Scholar 

  71. WILKUS R.J., CHILES J.A. - Electrophysiological changes during episodes of the Kleine-Levin syndrome. J. Neurol. Neurosurg. and Psychiat. 38, 1225–1231, 1975.

    Article  CAS  Google Scholar 

  72. WILL R.G., YOUNG J.P., THOMAS D.J. - Kleine-Levin syndrome: report of two cases with onset of symptoms precipitated by head traumatism. Br. J. Psychiatry, 152, 410–412, 1988.

    Article  PubMed  CAS  Google Scholar 

  73. WURTHMANN C., HARTUNG H.P., DENGLER W., GERHARDT P. - Kleine-Levin syndrome. The provocation of manic symptoms by an antidepressant and a therapeutic trial of carbamazepine. Dtsch. Med. Wochenschr. 114, 1528–1531, 1989.

    Article  CAS  Google Scholar 

  74. WYSS R., Psychotische Episoden bei einem Fall mit Kleine-Levin-Syndrom. Schweiz. Arch. Neurol. Psychiatr., 1,01,203,1968.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de Neurology B, Hôpital Gui de Chauliac, Montpellier, France

    M. Billiard

Authors
  1. M. Billiard
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hôpital Gui de Chauliac, Montpellier, France

    Michel Billiard

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Billiard, M. (2003). Recurrent hypersomnias. In: Billiard, M. (eds) Sleep. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0217-3_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0217-3_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4970-9

  • Online ISBN: 978-1-4615-0217-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation