Abstract
Protein C (PC) is a vital anticoagulant and antithrombotic in the blood coagulation cascade. Because PC is activated only when it is needed, it does not cause internal bleeding complications as does heparin or coumadin. PC deficiency can lead to blood clot formation in blood vessels, which can eventually lead to heart attack, stroke, skin necrosis, or even death. About 1,400 people worldwide currently die each day of septic shock and recently, PC has also been proven highly effective for septic shock treatment. Therefore, an inexpensive supply of PC is important for PC deficient patients, sepsis patients, and those undergoing major surgeries.
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Korah, L.K., Ahn, D.G., Kang, K.A. (2003). Development of an Economic Miniantibody Production Process for the Purification of Protein C (Anti-Coagulant/Anti-Thrombotic). In: Wilson, D.F., Evans, S.M., Biaglow, J., Pastuszko, A. (eds) Oxygen Transport To Tissue XXIII. Advances in Experimental Medicine and Biology, vol 510. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0205-0_21
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DOI: https://doi.org/10.1007/978-1-4615-0205-0_21
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