Prostanoids In Health and Disease; Lessons From Receptor-Knockout Mice

  • Takuya Kobayashi
  • Shuh Narumiya
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


There are eight types and subtypes of receptors for prostanoids including PGD receptor (DP), PGE receptors of EP1, EP2, EP3 and EP4 subtypes, PGF receptor (FP)

PGI receptor (IP) and TXA receptor (TP)1.


Patent Ductus Arteriosus Prostanoid Receptor Thrombotic Tendency Basal Blood Pressure Increase Bleeding Tendency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Coleman RA, Kennedy I, Humphrey PPA, Bunce K, Lumley P. Prostanoids and their receptors. In: Emmett, JC (ed.) Comprehensive Medicinal Chemistry, Vol. 3: Membranes and Receptors. Oxford: Pergamon Press, 643–714 (1990).Google Scholar
  2. 2.
    Ushikubi F, Nakajima M, Hirata M, Okuma M, Fujiwara M, Narumiya S. Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets. J. Biol. Chem. 264: 16496–16501 (1989).PubMedGoogle Scholar
  3. 3.
    Hirata M, Hayashi Y, Ushikubi F, Yokota Y, Kageyama R, Nakanishi S, Narumiya S. Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature 349: 617–620 (1991).PubMedCrossRefGoogle Scholar
  4. 4.
    Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors; structures, properties and functions. Physiol. Rev. 70: 1193–1226 (1999).Google Scholar
  5. 5.
    Murata T, Ushikubi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y, Ichikawa A, Aze Y, Tanaka T, Yoshida N, Ueno A, Oh-ishi S, Narumiya S. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388: 678–682 (1997).PubMedCrossRefGoogle Scholar
  6. 6.
    Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377: 239–242 (1995).PubMedCrossRefGoogle Scholar
  7. 7.
    Thomas DW, Mannon RB, Mannon PJ, Latour A, Oliver JA, Hoffman M, Smithies O, Koller BH, Coffman TM. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J. Clin. Invest. 102: 1994–2001 (1998).PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    irata T, Kakizuka A, Ushikubi F, Fuse I, Okuma M, Narumiya S. Arg60to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. J. Clin. Invest. 94: 1662–1667CrossRefGoogle Scholar
  9. 9.
    Davies P, Bailey PJ, Goldenberg MM, Ford-Huchinson AW. The role of arachidonic acid oxygenation products in pain and inflammation. Ann. Rev. Immunol. 2: 335–357 (1984).CrossRefGoogle Scholar
  10. 10.
    Smith GC. The pharmacology of the ductus arteriosus. Pharmacol. Rev. 50: 35–58 (1998)Google Scholar
  11. 11.
    Nguyen MT, Camenisch T, Snouwaert JN, Hicks E, Coffman TM, Anderson PAW, Malouf NM, Koller BH. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. NaturePubMedCrossRefGoogle Scholar
  12. 12.
    Segi, E., Sugimoto Y, Yamasaki A, Aze Y, Oida H, Nishimura T, Murata T, Matsuoka T, Ushikubi F, Hirose M, Tanaka T, Yoshida N, Narumiya S, Ichikawa A. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficeint mice. Biochem. Biophys. Res. Commun. 246: 7–12 (1998)Google Scholar
  13. 13.
    Matsuoka T, Hirata M, Tanaka H, Takahashi Y, Murata T, Kabashima K, Sugimoto Y, Kobayashi T, Ushikubi F, Aze Y, Eguchi N, Urade Y, Yoshida N, Kimura K, Mizoguchi A, Honda Y, Nagai H, Narumiya S. Prostaglandin D2 as a mediator of allergic asthma. Science in press(2000)Google Scholar
  14. 14.
    Sugimoto Y, Yamasaki A, Segi E, Tsuboi K, Aze Y, Nishimura T, Oida H, Yoshida N, Tanaka T, Katsuyama M, Hasumoto K, Murata T, Hirata M, Ushikubi F, Negishi M, Ichikawa A, Narumiya S. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277: 681–684 (1997)PubMedCrossRefGoogle Scholar
  15. 15.
    Ushikubi F, Segi E, Sugimoto Y, Murata T, Matsuoka T, Kobayashi T, Hizaki H, Tuboi K, Katsuyama M, Ichikawa A, Tanaka T, Yoshida N, Narumiya S. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 395: 281–284 (1998)Google Scholar
  16. 16.
    Sakuma Y, Tanaka K, Suda M Yasoda A, Natsui K, Tanaka I, Ushikubi F, Narumiya S, Sugimoto Y, Ichikawa A, Nakao K. Essential involvement of EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide. J. Bone Mineral Res. 15: 218–227 (2000)CrossRefGoogle Scholar
  17. 17.
    Hizaki H, Segi E, Sugimoto Y, Hirose M, Saji T, Ushikubi F, Matsuola T, Noda Y, Tanaka T, Yoshida N, Narumiya S, Ichikawa A. Abortive expansion of the cumuluc and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2. Proc Natl Acd Sci USA 96: 10501–10506 (1999).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Takuya Kobayashi
    • 1
  • Shuh Narumiya
    • 1
  1. 1.Department of PharmacologyKyoto University Faculty of MedicineKyotoJapan

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