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Sequence Determinants For The Positional Specificity Of Lipoxygenases

  • Kristin Schwarz
  • Monika Anton
  • Hartmut Kuhn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Lipoxygenases (LOXs) constitute a heterogeneous family of lipid peroxidizing enzymes, which catalyze the dioxygenation of free and/or esterified polyunsaturated fatty acids. In mammals the various LOX isoforms are categorized with respect to their positional specificity of arachidonic acid oxygenation into 5-, 8-, 12- and 15-LOXs (Brash, 1999; Kuhn and Thiele, 1999). 5-LOX are key enzymes in the biosynthesis of leukotrienes, which are important mediators of inflammatory and anaphylactic diseases (Drazen et al., 1999). Mammalian 15-LOXs have been implicated in PPARy-mediated cell signaling (Huang et al., 1999), in cell development and maturation (Rapoport et al., 1990; van Leyen et al., 1998) as well as in the pathogenesis of atherosclerosis (Cyrus et al., 1999).

Keywords

Arachidonic Acid Sequence Determinant Positional Specificity Mutant A424F Soybean Lipoxygenase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kristin Schwarz
    • 1
  • Monika Anton
    • 1
  • Hartmut Kuhn
    • 1
  1. 1.Institute of BiochemistryUniversity Clinics Charité, Humboldt-UniversityBerlinF.R. Germany

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