Sequence Determinants For The Positional Specificity Of Lipoxygenases

  • Kristin Schwarz
  • Monika Anton
  • Hartmut Kuhn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Lipoxygenases (LOXs) constitute a heterogeneous family of lipid peroxidizing enzymes, which catalyze the dioxygenation of free and/or esterified polyunsaturated fatty acids. In mammals the various LOX isoforms are categorized with respect to their positional specificity of arachidonic acid oxygenation into 5-, 8-, 12- and 15-LOXs (Brash, 1999; Kuhn and Thiele, 1999). 5-LOX are key enzymes in the biosynthesis of leukotrienes, which are important mediators of inflammatory and anaphylactic diseases (Drazen et al., 1999). Mammalian 15-LOXs have been implicated in PPARy-mediated cell signaling (Huang et al., 1999), in cell development and maturation (Rapoport et al., 1990; van Leyen et al., 1998) as well as in the pathogenesis of atherosclerosis (Cyrus et al., 1999).


Arachidonic Acid Sequence Determinant Positional Specificity Mutant A424F Soybean Lipoxygenase 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kristin Schwarz
    • 1
  • Monika Anton
    • 1
  • Hartmut Kuhn
    • 1
  1. 1.Institute of BiochemistryUniversity Clinics Charité, Humboldt-UniversityBerlinF.R. Germany

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