Biphasic Regulation of Leukocyte Trafficking by Lipoxins

  • Catherine Stenson
  • Siobhan Mitchell
  • David Lappin
  • Hugh R. Brady
  • Catherine Godson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Polymorphonuclear neutrophil (PMN) recruitment from blood to an extravascular inflammatory focus is an essential component of host defence. This is effected by chemotactic motion of PMNs, adhesion to endothelial cells at the site of inflammation and transmigration into the interstitium. Within the interstitium PMN contribute to host defence by phagocytosis and subsequent killing of invading microorganisms and release of free radicals and cytotoxins. Efficient removal of PMN from an inflammatory focus is necessary to limit PMN-mediated injury to host tissue and to terminate the inflammatory response (1,2). This is effected, at least in part, by phagocytosis of apoptotic PMN by macrophages (M4) and by `semi-professional’ phagocytes such as renal mesangial cells (2-4). Several lines of evidence suggest that the ‘spontaneous’ resolution of inflammation is a dynamically regulated process that includes metabolic dissipation of local chemotactic gradients and the generation of endogenous `braking signals’ which facilitate a return of tissue architecture and function to the premorbid state.


Mesangial Cell Leukocyte Trafficking Apoptotic Neutrophil Vitronectin Receptor Renal Mesangial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Catherine Stenson
    • 1
  • Siobhan Mitchell
    • 1
  • David Lappin
    • 1
  • Hugh R. Brady
    • 1
  • Catherine Godson
    • 1
  1. 1.Centre for Molecular Inflammation and Vascular Research, Department of Medicine and TherapeuticsMater Misericordiae Hospital, The Conway Institute of Biomolecular and Biomedical Research, University CollegeDublinIreland

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