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Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells

  • Bruno L. Diaz
  • Hiroshi Fujishima
  • Adam Sapirstein
  • Joseph V. Bonventre
  • Jonathan P. Arm
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Leukotrienes and prostaglandins, derived from the oxidative metabolism of arachidonic acid12are potent lipid mediators of tissue inflammation.34The first step in the generation of these eicosanoids, is the liberation of esterified arachidonic acid from the sn-2 position of cell membrane glycerophospholipids by the action of phospholipase A2 (PLA2)5. The family of mammalian PLA2enzymes includes the 85-kDa group IV cytosolic PLA2(cPLA2); at least eight low molecular weight, cysteine-rich PLA2enzymes; and calcium-independent species of PLA2.6

Keywords

Arachidonic Acid Stem Cell Factor Cytosolic Phospholipase Secretory Phospholipase PLA2 Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Bruno L. Diaz
    • 1
    • 3
  • Hiroshi Fujishima
    • 1
    • 3
  • Adam Sapirstein
    • 2
    • 6
  • Joseph V. Bonventre
    • 1
    • 5
    • 7
  • Jonathan P. Arm
    • 1
    • 3
    • 4
  1. 1.Department of MedicineHarvard Medical SchoolBoston
  2. 2.Department of Anesthesia and Critical CareHarvard Medical SchoolBoston
  3. 3.Division of Rheumatology, Immunology, and AllergyBrigham and Women’s HospitalBoston
  4. 4.Partners’ Asthma CenterBrigham and Women’s HospitalBoston
  5. 5.Medical ServicesMassachusetts General HospitalBoston
  6. 6.Anesthesia ServicesMassachusetts General HospitalBoston
  7. 7.Division of Health SciencesHarvard-Massachusetts Institute of TechnologyBoston

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