Investigation Into the Involvement of Phospholipases A2 and Map Kinases in Modulation of Aa Release and Cell Growth in A549 Cells
Prostaglandins (PGs) act as local hormones to regulate both physiological and pathological responses and have been implicated as causative factors in the pathogenesis of many diseases, including inflammation, asthma, atherosclerosis and cancer. Additionally, PGs can also act as autocrine modulators of cell proliferation in several cell lines including the human lung adenocarcinoma A549 cell line (Croxtall & Flower, 1992). PGE2 production is regulated both by the release of AA from cellular phospholipids by PLA2 enzymes and by the conversion of AA to PGH2 by the enzyme cyclo-oxygenase (COX).
KeywordsA549 Cell PGE2 Production PGE2 Release PLA2 Inhibitor Human Lung Adenocarcinoma A549 Cell
Unable to display preview. Download preview PDF.
- Wissing, D., Mouritzen, H., Egeblad,M., Poirier, G.G. & Jaattela, M. (1997). Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor induced apoptosis. Proc. Natl. Acad. Sci. USA 94,5073–5077.Google Scholar