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Investigation Into the Involvement of Phospholipases A2 and Map Kinases in Modulation of Aa Release and Cell Growth in A549 Cells

  • Qamrul G. Choudhury
  • Diane T. Mckay
  • Roderick J. Flower
  • Jamie D. Croxtall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Prostaglandins (PGs) act as local hormones to regulate both physiological and pathological responses and have been implicated as causative factors in the pathogenesis of many diseases, including inflammation, asthma, atherosclerosis and cancer. Additionally, PGs can also act as autocrine modulators of cell proliferation in several cell lines including the human lung adenocarcinoma A549 cell line (Croxtall & Flower, 1992). PGE2 production is regulated both by the release of AA from cellular phospholipids by PLA2 enzymes and by the conversion of AA to PGH2 by the enzyme cyclo-oxygenase (COX).

Keywords

A549 Cell PGE2 Production PGE2 Release PLA2 Inhibitor Human Lung Adenocarcinoma A549 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Qamrul G. Choudhury
    • 1
  • Diane T. Mckay
    • 1
  • Roderick J. Flower
    • 1
  • Jamie D. Croxtall
    • 1
  1. 1.The William Harvey Research Institute, St. Bartholomew’s and the Royal London School of Medicine and Dentistry (Queen Mary and Westfield College)Department of Biochemical PharmacologyLondon EC1M 6BQ.

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