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Targeted gene disruption of the prostaglandin e2 ep2 receptor

  • Richard M. Breyer
  • Christopher R. J. Kennedy
  • Yahua Zhang
  • Youfei Guan
  • Matthew D. Breyer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Prostaglandins comprise a diverse family of autacoids derived from cyclooxygenase (COX) metabolism of arachidonic acid to PGG/H2, leading to the generation of five principal bio-active prostaglandin (PG) metabolites: PGE2, PGF2a, PGD2, PGI2, and TXA2 1. The PGs play a role in a broad range of physiologic activities including modulating inflammation, ovulation and arterial blood pressure. These PG metabolites exert their effects at least in part by interacting with distinct G-protein coupled receptors (GPCRs) 2, each with distinct ligand selectivity and signal transduction pathways.

Keywords

Mean Arterial Pressure Selective Agonist Prostanoid Receptor Target Gene Disruption Null Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Richard M. Breyer
    • 1
    • 2
  • Christopher R. J. Kennedy
    • 1
  • Yahua Zhang
    • 1
  • Youfei Guan
    • 1
  • Matthew D. Breyer
    • 1
    • 3
    • 4
  1. 1.Departments of Medicine (Division of Nephrology)Vanderbilt University Division of NephrologyNashvilleUSA
  2. 2.PharmacologyVanderbilt University Division of NephrologyNashvilleUSA
  3. 3.Molecular Physiology and BiophysicsVanderbilt University Division of NephrologyNashvilleUSA
  4. 4.Veterans Administration Medical Center, and Vanderbilt University School of MedicineVanderbilt University Division of NephrologyNashvilleUSA

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