Leukotrienes and the Pulmonary Vascular Bed
The antigenic stimulation of respiratory tissues has always been associated with the release of slow reacting substance of anaphylaxis (SRS-A), an entity which is now known to be a composite of metabolites of the 5-lipoxygenase enzymatic pathway, namely, the cysteinyl-leukotrienes (LTC4, LTD4 and LTE4). Evidence that these mediators may play a role in asthma was based on the clinical observations that several cell types that produce cysteinyl-leukotrienes are present in increased numbers in the lung of asthmatic patients. Furthermore, these metabolites were detected in biological fluids derived from asthmatics following allergen inhalation. Such clinical data implicated the cysteinyl-leukotrienes in not only the allergic reactions to inhaled allergens but also supported the notion that these mediators may play a role in asthma.
KeywordsPulmonary Artery Pulmonary Vein Vascular Preparation Arterial Preparation Contractile Factor
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