Analysis of the Transcriptional Regulation of Mouse Prostacyclin Synthase Gene

  • Susumu Ohkawara
  • Chieko Yokoyama
  • Manabu Shimonishi
  • Tadashi Tanabe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Prostacyclin (PGI2) is a powerful vasodilator and inhibits the platelet aggregation and the abnormal growth of smooth muscle cells.’ It is therefore considered to play a key role in vasoprotection and its decrease causes vascular disease such as atherosclerosis, pulmonary hypertension and myocardial infarction.


Nuclear Extract Translational Start Site Bovine Aortic Endothelial Cell Unlabeled Probe Basal Promoter Activity 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Susumu Ohkawara
    • 1
  • Chieko Yokoyama
    • 1
  • Manabu Shimonishi
    • 1
  • Tadashi Tanabe
    • 1
  1. 1.Department of PharmacologyNational Cardiovascular Center Research InstituteOsakaJapan

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