Effects Of Overexpression Of Prostacyclin Synthase In Vascular Smooth Muscle Cells
Prostacyclin (PGI2) generated mainly by blood vessels, is a short-lived endogenous inhibitor of platelet aggregation and a potent vasodilator, contributing to the maintenance of homeostasis in vascular system., 2 In addition, exogenously added PGI2 and its stable analogues inhibited the growth of vascular smooth muscle cells (VSMC).3-6 However, it is not known if the locally synthesized PGI2 would similarly inhibit the growth in an autocrine and for paracrine manner.
KeywordsVascular Smooth Muscle Cell Vehicle Group Left Carotid Artery Balloon Injury Prostacyclin Analogue
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