Catalytic Properties of Purified Recombinant Anandamide Amidohydrolase
The major degradative pathway of anandamide, an endogenous ligand for cannabinoid receptors, is its enzymatic hydrolysis to arachidonic acid and ethanolamine.1The enzyme responsible for this reaction has been referred to as anandamide amidohydrolase23or fatty acid amide hydrolase.4‘N-Acylethanolamine amidohydrolase’ reported much earlier by Schmid and co-workers5is probably identical to this enzyme.
KeywordsArachidonic Acid Fatty Acid Amide Hydrolase Porcine Brain Resin Column Chromatography Relative Hydrolysis Rate
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- 5.P.C. Schmid, M.L. Zuzarte-Augustin, and H.H.O. Schmid, Properties of rat liver N-acylethanolamine amidohydrolaseJ. Biol. Chem.14145:260 (1985).Google Scholar